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<p>Male fertility is strongly affected by the overexpression of free radicals induced by heavy metals. The aim of this study was to produce nanoparticles from the agro-food waste, <i>Cucumeropsis mannii</i> melon seed husk extract (MSHE), whose burned seeds in Nigeria become incorporated into the soil contributing to pollution; and to propose a potential remediation biomarker adoptable to a metal-exposed animal model. Sol–gel precipitated melon husk silica nanoparticles were characterized by spectrophotometric and X-ray diffraction analysis. Biochemical and histopathological tests were performed on male albino rats divided into 8 groups orally exposed to Ni, Al, and Ni/Al both alone as well as co-administrated with MSHE at several dosages. Metal exposure reduced levels of plasma gonadotropin hormones follicle-stimulating hormone (FSH), Luteinizing Hormone (LH), and the sex steroid hormone testosterone, but MSHE co-administration increased them. MSHE treatment alone also raised FSH and LH levels compared to the metal-exposed groups. Plasma gonadotropin prolactin (PRL) levels were higher in each group examined, whereas MSHE co-administration significantly lowered them. Additionally, MSHE treatment alone exhibited lower PRL levels than the mixture-exposed groups and increased testosterone levels. Plasma hormonal results were confirmed by regeneration of testis architecture, testis lipid peroxidation decreases, and testis antioxidant increases. Use of agro-food waste nanoparticles has significant implications as evaluated with male albino rat plasma hormone levels. MSHE may ameliorate Ni–Al mixture-induced testicular toxicity and may be a useful future therapeutic tool.</p> Graphical abstract <p></p>

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Testis metal toxicity remediation by agro-food waste: evidence of a protective effect of melon seed husk extract Cucumeropsis mannii silica nanoparticles on gonadotropin and sex steroid hormones

  • 期刊论文

  • 发表日期：

    2025年2月21日

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  • Chidinma P. Anyachor,
  • Orish Ebere Orisakwe,
  • Chinna N. Orish,
  • Costantino Parisi,
  • Rubina Vangone,
  • Valeria Guerretti,
  • Loredana Assisi,
  • Doris N. Ajibo,
  • Baridoo Donatus Dooka,
  • Kenneth M. Ezealisiji,
  • Emidio M. Sivieri,
  • Giulia Guerriero

摘要

Male fertility is strongly affected by the overexpression of free radicals induced by heavy metals. The aim of this study was to produce nanoparticles from the agro-food waste, Cucumeropsis mannii melon seed husk extract (MSHE), whose burned seeds in Nigeria become incorporated into the soil contributing to pollution; and to propose a potential remediation biomarker adoptable to a metal-exposed animal model. Sol–gel precipitated melon husk silica nanoparticles were characterized by spectrophotometric and X-ray diffraction analysis. Biochemical and histopathological tests were performed on male albino rats divided into 8 groups orally exposed to Ni, Al, and Ni/Al both alone as well as co-administrated with MSHE at several dosages. Metal exposure reduced levels of plasma gonadotropin hormones follicle-stimulating hormone (FSH), Luteinizing Hormone (LH), and the sex steroid hormone testosterone, but MSHE co-administration increased them. MSHE treatment alone also raised FSH and LH levels compared to the metal-exposed groups. Plasma gonadotropin prolactin (PRL) levels were higher in each group examined, whereas MSHE co-administration significantly lowered them. Additionally, MSHE treatment alone exhibited lower PRL levels than the mixture-exposed groups and increased testosterone levels. Plasma hormonal results were confirmed by regeneration of testis architecture, testis lipid peroxidation decreases, and testis antioxidant increases. Use of agro-food waste nanoparticles has significant implications as evaluated with male albino rat plasma hormone levels. MSHE may ameliorate Ni–Al mixture-induced testicular toxicity and may be a useful future therapeutic tool.

Graphical abstract