Objective <p>This study aimed to describe the isokinetic strength profile of the shoulder and elbow muscles in elite wheelchair basketball players in the low-point (without trunk control) and high-point (with trunk control) classes, examining both inter-limb and intra-limb strength and identifying any asymmetries that may be present.</p> Methods <p>14 elite wheelchair basketball players (each group of 7 players) participated in this study. A Biodex dynamometer was used to measure the internal and external rotator of the glenohumeral muscle and Elbow flexors and extensors strength at 60°/s and 180°/s velocities in a concentric/concentric mode.</p> Results <p>The low-point class players had stronger shoulder internal rotation (IR) muscles at 60◦/s velocity movement on the dominant side and stronger external rotation (ER) muscles at 180◦/s velocity. They also generated higher amounts of peak torque to body weight ratio in elbow extension (EE) and elbow flexion (EF) muscles than the high-point class players. This study found inter-limb asymmetries in the IR at both velocities in low-point class players and at 60°/s velocity in high-point class players. Additionally, high-point class players showed inter-limb asymmetry at 60°/s in ER muscles. No intra-limb asymmetries were observed in either group except for peak torque at 180°/s. Borderline inter-limb asymmetries in the EE strength at 60°/s velocity in low-point class players and 180°/s velocity in high-point class players were observed and moderate inter-limb asymmetries in EF muscles at both velocities in high-point class players. Intra-limb asymmetries were observed in both groups at both velocities.</p> Conclusion <p>This study may indicate that low-point class players rely more on their upper limbs than high-point class players due to lacking trunk muscle force. This information may be useful for focusing on selective muscle strengthening in physical preparation programs and preventing overuse injuries.</p>