<p>Lead (Pb⁺²) exposure is the primary environmental-related issue affecting youngsters and females. It readily crosses the placental barrier, where its higher fetal absorption disrupts neurodevelopment through oxidative stress, inflammation, and mitochondrial and synaptic dysfunction, ultimately causing cognitive deficits in offspring. Natural products make a significant contribution to the development of agents that can mitigate the harmful effects of heavy metal pollution. In this study, the protective role of <i>Allium sativum</i> (garlic extract, GE) supplement and 8 weeks of aerobic exercise (AE) training was elicited against Pb⁺² contamination. The cytotoxicity, IC₅₀, and LD₅₀ of lead were first assessed in normal HSF 1184 fibroblast cells using the MTT assay to predict a safe in vivo dose, which was subsequently chosen and employed for injections in animal groups. This study investigates the synergistic effects of GE supplementation and AE training on mitigating cognitive impairments in the first-generation offspring of pregnant mice exposed to lead. In the in vivo experiment, pregnant Balb/C mice exposed to lead received GE supplementation from gestational day 1 (GD1) until day 14 (GD14), during which they also underwent a regimen of AE training. At the end of this research, the offspring were subjected to behavioral evaluations using the step-through DLB, ORT, and MWM tests. The findings revealed that the combined administration of GE with Pb²⁺, together with 8 weeks of AE training, ameliorated the most impaired ORT, MWM, and behavioral indices, and increased the total time spent by mice in the light room. These findings suggest that GE supplementation combined with AE training can partially counteract lead-induced cognitive impairments in offspring.</p>