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Purpose <p>This study aimed to compare the acute effects of two distinct resistance exercise (RE) protocols on circulating levels of HSP27, phosphorylated HSP27 (pHSP27), IL-6, IL-1β, IL-10, and TNF-α in trained postmenopausal women.</p> Methods <p>Thirteen resistance-trained postmenopausal women participated in a randomized crossover trial involving two RE protocols: high-load (HL: 90% 1RM, 6 repetitions per set, 3 sets, 3-min rest) and low-load (LL: 50% 1RM, 20 repetitions per set, 3 sets, 1.5-min rest). Each session included seven exercises and was separated by a 7-day washout. Blood samples were collected at baseline (PRE), immediately post-exercise (POST), and 1-h post-exercise (1H).</p> Results <p>Both protocols were performed near concentric failure (repetitions in reserve: HL = 0.91 ± 0.58; LL = 2.41 ± 1.79). LL elicited higher blood lactate (↑92%, <i>p</i> = 0.027) and training volume (↑86%, <i>p</i> &lt; 0.001). Only HL significantly increased circulating HSP27 levels: + 49% from PRE to POST (<i>p</i> = 0.005) and + 66% from PRE to 1H (<i>p</i> &lt; 0.001). LL did not significantly affect HSP27. IL-6 levels rose post-exercise (<i>p</i> = 0.011), with no significant difference between the protocols (<i>p</i> = 0.239). No significant changes were observed in pHSP27, IL-10, IL-1β, or TNF-α.</p> Conclusion <p>High-load resistance training acutely increases circulating HSP27 in trained postmenopausal women. IL-6 levels rise after RE regardless of load, while pHSP27, IL-10, IL-1β, and TNF-α remain unchanged after a single session.</p>

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Modulation of HSP27 and inflammatory cytokines by different resistance training protocols in postmenopausal women

  • 期刊论文

  • 发表日期：

    2025年10月19日

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  • Augusto Corrêa de Queiroz Freitas,
  • Cláudio Lera Orsatti,
  • Anna Victória Bernardes e Borges,
  • Marcos Vinícius da Silva,
  • Guilherme Vannucchi Portari,
  • Markus Vinicius Campos Souza,
  • Fábio Lera Orsatti

摘要

Purpose

This study aimed to compare the acute effects of two distinct resistance exercise (RE) protocols on circulating levels of HSP27, phosphorylated HSP27 (pHSP27), IL-6, IL-1β, IL-10, and TNF-α in trained postmenopausal women.

Methods

Thirteen resistance-trained postmenopausal women participated in a randomized crossover trial involving two RE protocols: high-load (HL: 90% 1RM, 6 repetitions per set, 3 sets, 3-min rest) and low-load (LL: 50% 1RM, 20 repetitions per set, 3 sets, 1.5-min rest). Each session included seven exercises and was separated by a 7-day washout. Blood samples were collected at baseline (PRE), immediately post-exercise (POST), and 1-h post-exercise (1H).

Results

Both protocols were performed near concentric failure (repetitions in reserve: HL = 0.91 ± 0.58; LL = 2.41 ± 1.79). LL elicited higher blood lactate (↑92%, p = 0.027) and training volume (↑86%, p < 0.001). Only HL significantly increased circulating HSP27 levels: + 49% from PRE to POST (p = 0.005) and + 66% from PRE to 1H (p < 0.001). LL did not significantly affect HSP27. IL-6 levels rose post-exercise (p = 0.011), with no significant difference between the protocols (p = 0.239). No significant changes were observed in pHSP27, IL-10, IL-1β, or TNF-α.

Conclusion

High-load resistance training acutely increases circulating HSP27 in trained postmenopausal women. IL-6 levels rise after RE regardless of load, while pHSP27, IL-10, IL-1β, and TNF-α remain unchanged after a single session.