Objectives <p>The aim of this research was to compare the effect of low and moderate intensity aerobic training on cardiac Apo proteins in diabetic rats.</p> Methods <p>Thirty male Wistar rats were randomly divided into three groups: low-intensity aerobic exercise, moderate-intensity aerobic exercise group, and control group. Streptozotocin drug was used to make the animals diabetic. Seventy-two hours after streptozotocin injection, fasting blood glucose above 126&#xa0;mg/dl was considered as a criterion for the rats to have diabetes. The rats were trained in experimental groups for 8&#xa0;weeks. Running speed in the low intensity training group was 5–8&#xa0;m per minute, equivalent to 50–60% of VO₂max and in the medium intensity training group, the speed was 22–25&#xa0;m per minute, equivalent to 80% of max2Vo and the control group of no intervention. At the end of the eighth week, all animals were anesthetized after a night of fasting and blood samples were collected from the heart. The research data were analyzed with statistical methods of one-way analysis of variance at a significance level of less than 5%.</p> Results <p>The results of this research showed that 8&#xa0;weeks of low and medium intensity aerobic training has an effect on cardiac Apo proteins A and B in diabetic rats and moderate intensity training caused a greater increase in Apo protein A and a greater decrease in Apo protein B compared to low intensity training.</p> Conclusion <p>Therefore, it can be concluded that aerobic exercise with moderate intensity is a better solution to deal with the indicators of cardiovascular diseases in people with diabetes.</p>