Scholarlink

Purpose <p>Decreased muscle mass was a risk factor for osteoarthritis (OA). It could be more accurately assessed by muscle quality index (MQI), which considered arm or appendicular skeletal muscle mass (ASM) and handgrip strength (HGS). We aimed to evaluate association between MQI and OA in aged 20–59 American adults.</p> Materials and methods <p>This cross-sectional analysis included 4,491 participants (aged 20–59) from 2011 to 2014 NHANES. HGS and ASM were evaluated by hand dynamometer and DXA. MQI<sub>total</sub> was calculated by HGS/ASM (kg/kg). OA was self-reported. Multivariate logistic regression and RCS were used to evaluate the association between MQI<sub>total</sub> and OA. Discriminatory capability and clinical utility were evaluated by ROC and DCA curves.</p> Results <p>Weighted data were representative of approximately 7 million US young and middle-aged adults diagnosed with OA (mean age 48.59&#xa0;years, female 60.68%). There was a 28% decrease in OA for every 1-unit increase in MQI<sub>total</sub> [OR (95% CI): 0.72 (0.53, 0.97)] after fully adjustment. Compared to extremely low group, normal MQI<sub>total</sub> was associated with almost 50% lower OA [0.54 (0.36, 0.82)]. No significant interaction was observed in subgroup analysis. RCS indicated that the association was non-linear (non-linearity <i>P</i> = 0.027). ROC analysis demonstrated that MQI<sub>total</sub> could effectively predict OA (AUC = 0.801) in fully adjusted model, and DCA displayed threshold exceeding over 40%, providing high clinical practicability.</p> Conclusion <p>In summary, low muscle mass index could indicate risk for OA patients. Early detection of muscle decline in OA is vital, as muscle weakness can lead to serious outcomes. Targeted enhancement of muscle mass may help reduce OA prevalence.</p> Graphical abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Association of muscle quality index with osteoarthritis in young and middle-aged American adults

  • 期刊论文

  • 发表日期：

    2025年4月26日

查看全文
  • Jingtao Huang,
  • Haoxian Tang,
  • Shicheng Jia,
  • Jiayou Chen,
  • Rongji Liang,
  • Cuiyun Tan,
  • Yuxiang Ren,
  • Jianjing Lin,
  • Xintao Zhang

摘要

Purpose

Decreased muscle mass was a risk factor for osteoarthritis (OA). It could be more accurately assessed by muscle quality index (MQI), which considered arm or appendicular skeletal muscle mass (ASM) and handgrip strength (HGS). We aimed to evaluate association between MQI and OA in aged 20–59 American adults.

Materials and methods

This cross-sectional analysis included 4,491 participants (aged 20–59) from 2011 to 2014 NHANES. HGS and ASM were evaluated by hand dynamometer and DXA. MQItotal was calculated by HGS/ASM (kg/kg). OA was self-reported. Multivariate logistic regression and RCS were used to evaluate the association between MQItotal and OA. Discriminatory capability and clinical utility were evaluated by ROC and DCA curves.

Results

Weighted data were representative of approximately 7 million US young and middle-aged adults diagnosed with OA (mean age 48.59 years, female 60.68%). There was a 28% decrease in OA for every 1-unit increase in MQItotal [OR (95% CI): 0.72 (0.53, 0.97)] after fully adjustment. Compared to extremely low group, normal MQItotal was associated with almost 50% lower OA [0.54 (0.36, 0.82)]. No significant interaction was observed in subgroup analysis. RCS indicated that the association was non-linear (non-linearity P = 0.027). ROC analysis demonstrated that MQItotal could effectively predict OA (AUC = 0.801) in fully adjusted model, and DCA displayed threshold exceeding over 40%, providing high clinical practicability.

Conclusion

In summary, low muscle mass index could indicate risk for OA patients. Early detection of muscle decline in OA is vital, as muscle weakness can lead to serious outcomes. Targeted enhancement of muscle mass may help reduce OA prevalence.

Graphical abstract