Scholarlink

Purpose <p>Obesity hypoventilation syndrome (OHS) is a severe consequence of the global obesity epidemic. This study compared the patterns and severity of nocturnal oxygen desaturation in adults with OHS and obstructive sleep apnea (OSA).</p> Methods <p>This case–control study conducted at King Abdulaziz University Hospital reviewed polysomnography (PSG) records (2016–2022) of patients with OHS and OSA. The data included demographics, BMI, and indices (apnea–hypopnea index [AHI], baseline/minimum SpO₂, percentage of total sleep time with SpO₂ &lt; 90 percent [T90], total sleep time). GraphPad Prism was used for the analysis. Data were summarized as medians and interquartile ranges (IQR). Mann–Whitney U and Kruskal–Wallis tests with Dunn’s test were used to compare groups. Fisher’s exact test analyzed categorical variables (<i>p</i> &lt; 0.05). The study was approved by the Ethics Committee.</p> Results <p>Of the 199 PSG studies, 15 patients met OHS criteria and 184 had OSA. The OHS group had a higher BMI (50.0 [47.0–55.0] kg m<sup>−2</sup>) than the OSA group (45.0 [32.0–48.8] kg m<sup>−2</sup>; <i>p</i> &gt; 0.001). Baseline SpO₂ (89 [86–94] vs. 95 [93–97]%; <i>p</i> = 0.001), SpO₂ nadir (72 [63–81]% vs 82 [74–88]%; <i>p</i> = 0.007), average SpO₂ (87 [86–94]% vs. 94 [92–95]%; <i>p</i> = 0.003) and T90 (71 [3–93]% vs 2 [0–18]%; <i>p</i> = 0.001) were worse in OHS. Age and AHI were similar. Women were older than men in both groups. Women with OHS showed lowest baseline SpO₂ (88%), nadir SpO₂ (67%), and highest T90 (91%), differing from other groups (<i>p</i> &lt; 0.05). AHI and sleep time remained similar.</p> Conclusion <p>Despite similar AHI, OHS is associated with a greater hypoxemic burden than OSA, especially in females. These findings underscore the need to consider both diagnosis and sex in sleep-disordered breathing to develop sex-specific treatment approaches.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Nocturnal hypoxemic burden in obesity hypoventilation syndrome compared to obstructive sleep apnea: a case–control study

  • 期刊论文

  • 发表日期：

    2026年6月29日

查看全文
  • Husam I. Alahmadi

摘要

Purpose

Obesity hypoventilation syndrome (OHS) is a severe consequence of the global obesity epidemic. This study compared the patterns and severity of nocturnal oxygen desaturation in adults with OHS and obstructive sleep apnea (OSA).

Methods

This case–control study conducted at King Abdulaziz University Hospital reviewed polysomnography (PSG) records (2016–2022) of patients with OHS and OSA. The data included demographics, BMI, and indices (apnea–hypopnea index [AHI], baseline/minimum SpO₂, percentage of total sleep time with SpO₂ < 90 percent [T90], total sleep time). GraphPad Prism was used for the analysis. Data were summarized as medians and interquartile ranges (IQR). Mann–Whitney U and Kruskal–Wallis tests with Dunn’s test were used to compare groups. Fisher’s exact test analyzed categorical variables (p < 0.05). The study was approved by the Ethics Committee.

Results

Of the 199 PSG studies, 15 patients met OHS criteria and 184 had OSA. The OHS group had a higher BMI (50.0 [47.0–55.0] kg m−2) than the OSA group (45.0 [32.0–48.8] kg m−2; p > 0.001). Baseline SpO₂ (89 [86–94] vs. 95 [93–97]%; p = 0.001), SpO₂ nadir (72 [63–81]% vs 82 [74–88]%; p = 0.007), average SpO₂ (87 [86–94]% vs. 94 [92–95]%; p = 0.003) and T90 (71 [3–93]% vs 2 [0–18]%; p = 0.001) were worse in OHS. Age and AHI were similar. Women were older than men in both groups. Women with OHS showed lowest baseline SpO₂ (88%), nadir SpO₂ (67%), and highest T90 (91%), differing from other groups (p < 0.05). AHI and sleep time remained similar.

Conclusion

Despite similar AHI, OHS is associated with a greater hypoxemic burden than OSA, especially in females. These findings underscore the need to consider both diagnosis and sex in sleep-disordered breathing to develop sex-specific treatment approaches.