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Purpose <p>Cross-sectional studies suggest that obstructive sleep apnea (OSA) is a potential risk factor for incident COVID-19 infection, but longitudinal studies are lacking.</p> Methods <p>Two surveys from a large general population cohort, the COVID-19 Outbreak Public Evaluation (COPE) Initiative, undertaken 147 ± 58 days apart were analyzed to determine whether the pre-existing OSA was a risk factor for the incidence of COVID-19.</p> Results <p>Of the 24,803 respondents completing the initial survey, 14,950 were negative for COVID-19; data from the follow-up survey were available for 2,325 respondents. Those with incident COVID-19 infection had a slightly higher prevalence of OSA (COVID-19+: 14.3 vs. COVID-19-: 11.5%, <i>p</i> = 0.068). Stratification by treatment status revealed that those untreated for their OSA were at greater risk for developing COVID-19 infection (OSA Untreated: 14.2 vs. OSA Treated: 7.4%, <i>p</i> ≤ 0.05). In a logistic regression model adjusted for comorbidities, demographic, socioeconomic factors, days between surveys and the interaction between vaccination status and OSA, incident COVID-19 infection was 1.94 times more likely in those with OSA (aOR: 1.94, 95% CI: 1.07–3.51, <i>p</i> ≤ 0.05). Stratification by treatment status revealed only untreated OSA participants were at greater risk for COVID-19 (aOR: 3.21, 95% CI: 1.25–8.23, <i>p</i> ≤ 0.05).</p> Conclusion <p>The evidence from this study confirms untreated OSA as a risk factor for acquiring COVID-19 infection and highlights the importance of actively treating and managing OSA as a preventative mechanism against COVID-19 disease.</p>

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Obstructive sleep apnea is a risk factor for incident COVID-19 infection

  • 期刊论文

  • 发表日期：

    2025年6月25日

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  • Stuart F. Quan,
  • Matthew D. Weaver,
  • Mark É. Czeisler,
  • Laura K. Barger,
  • Lauren A. Booker,
  • Mark E. Howard,
  • Melinda L. Jackson,
  • Christine F. McDonald,
  • Anna Ridgers,
  • Rebecca Robbins,
  • Prerna Varma,
  • Shantha M. W. Rajaratnam,
  • Charles A. Czeisler

摘要

Purpose

Cross-sectional studies suggest that obstructive sleep apnea (OSA) is a potential risk factor for incident COVID-19 infection, but longitudinal studies are lacking.

Methods

Two surveys from a large general population cohort, the COVID-19 Outbreak Public Evaluation (COPE) Initiative, undertaken 147 ± 58 days apart were analyzed to determine whether the pre-existing OSA was a risk factor for the incidence of COVID-19.

Results

Of the 24,803 respondents completing the initial survey, 14,950 were negative for COVID-19; data from the follow-up survey were available for 2,325 respondents. Those with incident COVID-19 infection had a slightly higher prevalence of OSA (COVID-19+: 14.3 vs. COVID-19-: 11.5%, p = 0.068). Stratification by treatment status revealed that those untreated for their OSA were at greater risk for developing COVID-19 infection (OSA Untreated: 14.2 vs. OSA Treated: 7.4%, p ≤ 0.05). In a logistic regression model adjusted for comorbidities, demographic, socioeconomic factors, days between surveys and the interaction between vaccination status and OSA, incident COVID-19 infection was 1.94 times more likely in those with OSA (aOR: 1.94, 95% CI: 1.07–3.51, p ≤ 0.05). Stratification by treatment status revealed only untreated OSA participants were at greater risk for COVID-19 (aOR: 3.21, 95% CI: 1.25–8.23, p ≤ 0.05).

Conclusion

The evidence from this study confirms untreated OSA as a risk factor for acquiring COVID-19 infection and highlights the importance of actively treating and managing OSA as a preventative mechanism against COVID-19 disease.