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Purpose <p>Radionuclide-labeled fibroblast activation protein inhibitor (FAPI) is an emerging tumor tracer. We sought to assess the uptake and diagnostic performance of <sup>18</sup>F-FAPI-42 PET/CT compared with simultaneous 2-deoxy-2[<sup>18</sup>F]fluoro-D-glucose (<sup>18</sup>F-FDG) PET/CT in primary and metastatic lesions in patients with malignant digestive system neoplasms and to determine the potential clinical benefit.</p> Procedures <p>Forty-two patients (men = 30, women = 12, mean age = 56.71 ± 13.26&#xa0;years) who underwent <sup>18</sup>F-FDG PET/CT and <sup>18</sup>F-FAPI-42 PET/CT simultaneously for diagnosis, staging, and restaging were enrolled. Quantitative data, including standardized uptake value (SUV), tumor-to-liver ratio (TLR), and tumor-to-blood pool ratio (TBR), were analyzed. Two independent readers performed a visual assessment of lesion number and location on PET/CT images. Interobserver agreement between two examinations was calculated using Cohen’s kappa (κ).</p> Results <p>Primary tumor locations included the liver (<i>n</i> = 20), stomach (<i>n</i> = 9), pancreas (<i>n</i> = 5), and intestine (<i>n</i> = 10). More intense <sup>18</sup>F-FAPI-42 uptake and higher tumor-to-background contrast were detected in most primary and metastatic lesions compared with <sup>18</sup>F-FDG, contributing to improved diagnostic accuracy ranging from 95.24% to 100%. Moreover, additional lesions showing <sup>18</sup>F-FAPI-42 uptake in primary, locoregional and distant metastatic lesions were visualized, especially in multiple liver and peritoneal metastases. Patient-based interobserver agreement varied from moderate to strong, with suboptimal outcomes observed in primary tumors (κ = 0.441, <i>P</i> = 0.01) and preferable results derived from metastatic liver and bone lesions (κ = 1 and 0.896, both <i>P</i> &lt; 0.01). <sup>18</sup>F-FAPI-42 PET/CT resulted in modified treatment strategies for 40.48% (17/42) of patients, while <sup>18</sup>F-FDG PET/CT led to altered therapeutic regimens in only 4.8% (2/42) of patients.</p> Conclusions <p>In selected patients with malignant digestive system neoplasms, our study shows that <sup>18</sup>F-FAPI-42 PET/CT is a promising alternative for assessing primary tumors and metastases and aiding staging, restaging, and decision-making, with higher uptake and better lesion visualization compared with <sup>18</sup>F-FDG. Additionally, it may shed light into the treatment selection and response assessment for FAP-targeted therapy or immunotherapy.</p>

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18F-FAPI-42 PET/CT and 18F-FDG PET/CT in Patients with Malignant Digestive System Neoplasms: A Head-to-Head Comparative Study

  • 期刊论文

  • 发表日期：

    2025年1月13日

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  • Min Xiong,
  • HongJi You,
  • Jingmin Feng,
  • Yipei Liu,
  • Xiaoming Luo,
  • Ying Liu,
  • Sheng-Nan Jiang

摘要

Purpose

Radionuclide-labeled fibroblast activation protein inhibitor (FAPI) is an emerging tumor tracer. We sought to assess the uptake and diagnostic performance of 18F-FAPI-42 PET/CT compared with simultaneous 2-deoxy-2[18F]fluoro-D-glucose (18F-FDG) PET/CT in primary and metastatic lesions in patients with malignant digestive system neoplasms and to determine the potential clinical benefit.

Procedures

Forty-two patients (men = 30, women = 12, mean age = 56.71 ± 13.26 years) who underwent 18F-FDG PET/CT and 18F-FAPI-42 PET/CT simultaneously for diagnosis, staging, and restaging were enrolled. Quantitative data, including standardized uptake value (SUV), tumor-to-liver ratio (TLR), and tumor-to-blood pool ratio (TBR), were analyzed. Two independent readers performed a visual assessment of lesion number and location on PET/CT images. Interobserver agreement between two examinations was calculated using Cohen’s kappa (κ).

Results

Primary tumor locations included the liver (n = 20), stomach (n = 9), pancreas (n = 5), and intestine (n = 10). More intense 18F-FAPI-42 uptake and higher tumor-to-background contrast were detected in most primary and metastatic lesions compared with 18F-FDG, contributing to improved diagnostic accuracy ranging from 95.24% to 100%. Moreover, additional lesions showing 18F-FAPI-42 uptake in primary, locoregional and distant metastatic lesions were visualized, especially in multiple liver and peritoneal metastases. Patient-based interobserver agreement varied from moderate to strong, with suboptimal outcomes observed in primary tumors (κ = 0.441, P = 0.01) and preferable results derived from metastatic liver and bone lesions (κ = 1 and 0.896, both P < 0.01). 18F-FAPI-42 PET/CT resulted in modified treatment strategies for 40.48% (17/42) of patients, while 18F-FDG PET/CT led to altered therapeutic regimens in only 4.8% (2/42) of patients.

Conclusions

In selected patients with malignant digestive system neoplasms, our study shows that 18F-FAPI-42 PET/CT is a promising alternative for assessing primary tumors and metastases and aiding staging, restaging, and decision-making, with higher uptake and better lesion visualization compared with 18F-FDG. Additionally, it may shed light into the treatment selection and response assessment for FAP-targeted therapy or immunotherapy.