Scholarlink

Background <p>The two-way relationship between metabolites and insomnia is not yet fully understood.</p> Objective <p>We investigated the bidirectional relationship between metabolites and insomnia using human genome-wide association study and mouse models to identify potential biomarkers.</p> Methods <p>We analyzed data from two large genome-wide association studies: one on insomnia (336,965 participants) and one on metabolites (7,824 participants). Genetic variants related to metabolites and insomnia were examined. In the animal study, 12 mice were divided into control and chronic sleep deprivation groups (<i>n</i> = 6 each). After 32 days, blood and fecal metabolites were analyzed.</p> Results <p>Higher oleate levels were linked to lower insomnia risk (<i>β</i>: -5.99, <i>p</i> = 0.01), but insomnia did not alter oleate levels. Insomnia increased glucose (<i>β</i>: 0.18, <i>p</i> = 0.002), mannose (<i>β</i>: 0.11, <i>p</i> = 0.02), and influenced six lipids and four amino acids. In mice, sleep deprivation lowered corticosterone (<i>p</i> = 0.03), raised glucose and mannose (<i>p</i> = 0.001), and reduced blood (<i>p</i> = 0.007) and fecal oleate (<i>p</i> = 0.05). Fecal 4-aminobutyric acid also decreased (<i>p</i> = 0.01).</p> Conclusions <p>Insomnia and metabolites exhibited a bidirectional relationship, with notable metabolic and hormonal changes in the animal model. Improving sleep hygiene and regular assessments may help mitigate insomnia-related metabolic disruptions.</p> Graphical Abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Causal relationships between insomnia and blood metabolome: a Mendelian randomization study with mouse experimental validation

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年5月24日

查看全文
  • Hsien-Yu Fan,
  • Cheng-Chia Hsieh,
  • Tsung-Po Chen,
  • Po-Jui Lai,
  • Hsin-Yin Hsu,
  • Chiu-Li Yeh,
  • Changwei W. Wu,
  • Kuo-Liong Chien,
  • Hui-Yu Huang,
  • Yu-Tang Tung

摘要

Background

The two-way relationship between metabolites and insomnia is not yet fully understood.

Objective

We investigated the bidirectional relationship between metabolites and insomnia using human genome-wide association study and mouse models to identify potential biomarkers.

Methods

We analyzed data from two large genome-wide association studies: one on insomnia (336,965 participants) and one on metabolites (7,824 participants). Genetic variants related to metabolites and insomnia were examined. In the animal study, 12 mice were divided into control and chronic sleep deprivation groups (n = 6 each). After 32 days, blood and fecal metabolites were analyzed.

Results

Higher oleate levels were linked to lower insomnia risk (β: -5.99, p = 0.01), but insomnia did not alter oleate levels. Insomnia increased glucose (β: 0.18, p = 0.002), mannose (β: 0.11, p = 0.02), and influenced six lipids and four amino acids. In mice, sleep deprivation lowered corticosterone (p = 0.03), raised glucose and mannose (p = 0.001), and reduced blood (p = 0.007) and fecal oleate (p = 0.05). Fecal 4-aminobutyric acid also decreased (p = 0.01).

Conclusions

Insomnia and metabolites exhibited a bidirectional relationship, with notable metabolic and hormonal changes in the animal model. Improving sleep hygiene and regular assessments may help mitigate insomnia-related metabolic disruptions.

Graphical Abstract