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Introduction <p>Right heart (RH), as a junction between the venous system and pulmonary circulation, gains great emphasis on exploring the relevant pathological mechanism of many cardiopulmonary diseases. Although these pathogensis researches centering on RH-related diseases advance, the physiological mechanism research of the RH is scarce.</p> Objectives <p>This study aimed to accurately unravel the metabolic features of normal trans-RH through non-targeted metabolomics.</p> Methods <p>Patent foramen ovale (PFO) participants with normal function of RH were recruited and their blood samples from superior vena cava (SVC) and pulmonary artery (PA) were collected through right cardiac catheterization. Non-targeted metabolomics analysis based on UHPLC-MS/MS was utilized to generate the metabolic feature of trans-RH by comparing the metabolites change from SVC to PA, revealing its physiological gradient metabolic mechanism.</p> Results <p>1060 metabolites were tentatively identified in blood samples from 28 PFO participants. 51 differential metabolites were defined based on screening criteria after flowing through RH, including 39 down-regulated metabolites and 12 up-regulated metabolites. Among them, phosphatidylcholines, sphingomyelins, amino acids, triacylglycerol, neopterin, and tetradecanedioic acid were the most relevant.</p> Conclusion <p>Our study provides a more profound and extensive understanding of the psychological metabolism of trans-RH, expanding the current knowledge of normal RH function and providing clues for the pathogenesis research of RH-related diseases.</p>

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Plasma non-targeted metabolomics unravels the metabolic features of normal trans-right heart

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年8月29日

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  • Xifeng Qian,
  • Yuanrui Deng,
  • Tingting Guo,
  • Xin Huang,
  • Chaowu Yan,
  • Xin Gao,
  • Yan Wu,
  • Xinxin Yan,
  • Zhiqiang Liu,
  • Song Hu,
  • Jiangshan Tan,
  • Lingtao Chong,
  • Shengsong Zhu,
  • Mingjie Ma,
  • Mengting Ye,
  • Lu Hua,
  • Jian Cao,
  • Xiaojian Wang

摘要

Introduction

Right heart (RH), as a junction between the venous system and pulmonary circulation, gains great emphasis on exploring the relevant pathological mechanism of many cardiopulmonary diseases. Although these pathogensis researches centering on RH-related diseases advance, the physiological mechanism research of the RH is scarce.

Objectives

This study aimed to accurately unravel the metabolic features of normal trans-RH through non-targeted metabolomics.

Methods

Patent foramen ovale (PFO) participants with normal function of RH were recruited and their blood samples from superior vena cava (SVC) and pulmonary artery (PA) were collected through right cardiac catheterization. Non-targeted metabolomics analysis based on UHPLC-MS/MS was utilized to generate the metabolic feature of trans-RH by comparing the metabolites change from SVC to PA, revealing its physiological gradient metabolic mechanism.

Results

1060 metabolites were tentatively identified in blood samples from 28 PFO participants. 51 differential metabolites were defined based on screening criteria after flowing through RH, including 39 down-regulated metabolites and 12 up-regulated metabolites. Among them, phosphatidylcholines, sphingomyelins, amino acids, triacylglycerol, neopterin, and tetradecanedioic acid were the most relevant.

Conclusion

Our study provides a more profound and extensive understanding of the psychological metabolism of trans-RH, expanding the current knowledge of normal RH function and providing clues for the pathogenesis research of RH-related diseases.