Scholarlink

<p>Endometriosis is a chronic gynecological condition characterized by endometrial tissue outside the uterine cavity. Recent research has focused on the relationship between the purinergic system and endometriosis. As a purinergic system component, extracellular adenosine triphosphate (ATP) has been involved as a crucial mediator of chronic pain associated with the disease, as well as P2X3 receptors, which play a key role in sensitization of nerve fibers and generation of nociceptive, neuropathic, and inflammatory pain. In addition, ectonucleotidases such as CD39 and CD73, which regulate ATP hydrolysis, have an altered expression in endometriotic lesions, contributing to extracellular ATP accumulation, intensifying inflammation and pain. Together, immune cells and their product are increased in endometriotic <i>foci</i> and promote the emergence of new lesions through their contribution to retrograde menstruation. Some studies have observed significant changes in mitochondrial respiration, notably decreased oxygen consumption in the affected endometrium. These various cellular processes that are mediated by ATP and adenosine in the uterine cavity and exert effects on immune defense will be herein reviewed in detail to investigate possible inhibitors, their activity, and potential exploration of the purinergic pathway as a therapeutic alternative.</p> Graphical abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

The role of purinergic P2X3 receptors and endometriosis-associated hyperalgesia

  • 期刊论文

  • 发表日期：

    2025年7月4日

查看全文
  • Kailane Paula Pretto,
  • Letícia de Souza Matias,
  • Bruna Dias de Oliveira,
  • Adinei Abadio Soares,
  • Camila Ferreira Puntel,
  • Yghor Augusto da Rocha Ricardo,
  • Yenidis Teilor Scheibel,
  • Débora Tavares de Resende e Silva

摘要

Endometriosis is a chronic gynecological condition characterized by endometrial tissue outside the uterine cavity. Recent research has focused on the relationship between the purinergic system and endometriosis. As a purinergic system component, extracellular adenosine triphosphate (ATP) has been involved as a crucial mediator of chronic pain associated with the disease, as well as P2X3 receptors, which play a key role in sensitization of nerve fibers and generation of nociceptive, neuropathic, and inflammatory pain. In addition, ectonucleotidases such as CD39 and CD73, which regulate ATP hydrolysis, have an altered expression in endometriotic lesions, contributing to extracellular ATP accumulation, intensifying inflammation and pain. Together, immune cells and their product are increased in endometriotic foci and promote the emergence of new lesions through their contribution to retrograde menstruation. Some studies have observed significant changes in mitochondrial respiration, notably decreased oxygen consumption in the affected endometrium. These various cellular processes that are mediated by ATP and adenosine in the uterine cavity and exert effects on immune defense will be herein reviewed in detail to investigate possible inhibitors, their activity, and potential exploration of the purinergic pathway as a therapeutic alternative.

Graphical abstract