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<p>Prodigiosin is a bioactive red pigment with antimicrobial and anticancer properties, offering a natural substitute for synthetic colorants. A pigment-producing strain, <i>Serratia marcescens</i> HMS, was isolated from air and identified via 16S rRNA sequencing (GenBank Accession No. PP456732.1; 100% similarity). Acetone yielded the highest pigment extraction efficiency (4.54 mg/L). Optimal production (6.98 mg/L) occurred in LB medium (pH 7) at 30 °C under shaking conditions (150 rpm). Sweet potato peels served as an effective low-cost and sustainable agricultural waste substrate for extracellular pigment production. The purified pigment was confirmed as prodigiosin using TLC, HPLC, FTIR, and GC–MS (C<sub>20</sub>H<sub>25</sub>N<sub>3</sub>O; m/z 323). The pigment displayed antimicrobial activity against <i>Bacillus subtilis</i> (inhibition zone: 12 mm), cytotoxicity against HepG2 and MCF-7 cells (IC<sub>50</sub>: 61.12 ± 2.64 and 87.86 ± 4.18 μg/mL, respectively), and α-glucosidase inhibitory activity (IC<sub>50</sub>: 380.27 ± 8.15 μg/mL). These results establish <i>S. marcescens</i> HMS as an efficient prodigiosin producer and highlight the pigment’s potential for pharmaceutical and industrial applications.</p> Graphical abstract <p></p>

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Bioproduction, characterization, and evaluation of the biological activities of prodigiosin from Serratia marcescens HMS

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年4月25日

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  • Hadeer O. Jaheen,
  • Hoda H. Yusef,
  • Soraya A. Sabry,
  • Mona E. M. Mabrouk

摘要

Prodigiosin is a bioactive red pigment with antimicrobial and anticancer properties, offering a natural substitute for synthetic colorants. A pigment-producing strain, Serratia marcescens HMS, was isolated from air and identified via 16S rRNA sequencing (GenBank Accession No. PP456732.1; 100% similarity). Acetone yielded the highest pigment extraction efficiency (4.54 mg/L). Optimal production (6.98 mg/L) occurred in LB medium (pH 7) at 30 °C under shaking conditions (150 rpm). Sweet potato peels served as an effective low-cost and sustainable agricultural waste substrate for extracellular pigment production. The purified pigment was confirmed as prodigiosin using TLC, HPLC, FTIR, and GC–MS (C20H25N3O; m/z 323). The pigment displayed antimicrobial activity against Bacillus subtilis (inhibition zone: 12 mm), cytotoxicity against HepG2 and MCF-7 cells (IC50: 61.12 ± 2.64 and 87.86 ± 4.18 μg/mL, respectively), and α-glucosidase inhibitory activity (IC50: 380.27 ± 8.15 μg/mL). These results establish S. marcescens HMS as an efficient prodigiosin producer and highlight the pigment’s potential for pharmaceutical and industrial applications.

Graphical abstract