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<p><i>Vibrio</i> spp. are ubiquitous in aquatic environments and can infect a broad range of hosts. Consumption of undercooked, <i>Vibrio</i>-contaminated seafood poses a serious threat to human health, frequently causing gastroenteritis, wound infections, and septicemia. Here, we report an <i>Enterococcus faecium</i> strain 10 − 1, which exhibits potent antagonistic activity against a broad spectrum of aquatic pathogenic <i>Vibrio</i> species. Its safety was systematically verified through phenotypic antibiotic resistance screening, as well as whole-genome analysis of virulence factors and mobile genetic elements. The strain displayed broad-spectrum anti-<i>Vibrio</i> activity in vitro, and its active components were remarkably stable after exposure to high temperature (121&#xa0;°C), extreme pH (2–10), lyophilization–rehydration, and long-term storage at low temperature. Furthermore, <i>E. faecium</i> 10 − 1 exhibited high tolerance to salinity and simulated gastrointestinal stress, underscoring its excellent probiotic potential. Collectively, our results demonstrate that <i>E. faecium</i> 10 − 1 represents a promising candidate probiotic for aquaculture applications, providing a foundation for developing next-generation microbes beneficial for aquatic animal production.</p>

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Characterization of Enterococcus faecium 10 − 1: A potential probiotic with broad-spectrum anti-Vibrio activity

  • 期刊论文

  • 发表日期：

    2026年3月31日

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  • Mengya Zhang,
  • Chunming Cheng,
  • Lingling Ma,
  • Haitong Hou

摘要

Vibrio spp. are ubiquitous in aquatic environments and can infect a broad range of hosts. Consumption of undercooked, Vibrio-contaminated seafood poses a serious threat to human health, frequently causing gastroenteritis, wound infections, and septicemia. Here, we report an Enterococcus faecium strain 10 − 1, which exhibits potent antagonistic activity against a broad spectrum of aquatic pathogenic Vibrio species. Its safety was systematically verified through phenotypic antibiotic resistance screening, as well as whole-genome analysis of virulence factors and mobile genetic elements. The strain displayed broad-spectrum anti-Vibrio activity in vitro, and its active components were remarkably stable after exposure to high temperature (121 °C), extreme pH (2–10), lyophilization–rehydration, and long-term storage at low temperature. Furthermore, E. faecium 10 − 1 exhibited high tolerance to salinity and simulated gastrointestinal stress, underscoring its excellent probiotic potential. Collectively, our results demonstrate that E. faecium 10 − 1 represents a promising candidate probiotic for aquaculture applications, providing a foundation for developing next-generation microbes beneficial for aquatic animal production.