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<p>Gene regulatory networks (GRNs) are crucial for understanding the physiological properties of the cells and the organisms as they reveal complex biomolecular interactions. GRNs provide insights into biochemical reactions that occur involving various genes, proteins, metabolites and transcription factors within the cell. GRNs are a powerful tool for understanding biomolecular interactions at the systems level, as even small changes in one part of the network can affect the entire cell system of an organism. The present review discusses the importance of GRNs, which are interrogated for a variety of purposes including in personalized medicine and in devising therapeutic solutions for various diseases. Our review also describes various gene regulatory networks and their significance in diverse areas of biotechnology. Finally, the gene networks tools for drug discovery, drug targeting and delivery, and treatment in precision medicine are described. Our review highlights the GRN tools and technologies, their prospects and the challenges associated with the interpretation of the networks and translational potential of the new insights gained.</p>

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Gene regulatory and biomolecular networks and their multifaceted biotechnological applications

  • 期刊论文

  • 发表日期：

    2026年3月24日

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  • Srabani Kar,
  • Manideepa Barua,
  • Eetika Chot,
  • Rajeev K. Azad,
  • Pratyoosh Shukla

摘要

Gene regulatory networks (GRNs) are crucial for understanding the physiological properties of the cells and the organisms as they reveal complex biomolecular interactions. GRNs provide insights into biochemical reactions that occur involving various genes, proteins, metabolites and transcription factors within the cell. GRNs are a powerful tool for understanding biomolecular interactions at the systems level, as even small changes in one part of the network can affect the entire cell system of an organism. The present review discusses the importance of GRNs, which are interrogated for a variety of purposes including in personalized medicine and in devising therapeutic solutions for various diseases. Our review also describes various gene regulatory networks and their significance in diverse areas of biotechnology. Finally, the gene networks tools for drug discovery, drug targeting and delivery, and treatment in precision medicine are described. Our review highlights the GRN tools and technologies, their prospects and the challenges associated with the interpretation of the networks and translational potential of the new insights gained.