<p>The prevalence of microplastics in ecosystems and the widespread contamination they cause in terrestrial and aquatic ecosystems has raised global concern over the decade. Due to the widespread distribution and complexity of microplastics, they pose a considerable risk for both terrestrial and aquatic ecosystems. Now, maritime systems are the subject of more than 96% of MPs' studies. Though it has been established that sources are based on land for most of the aquatic MP contamination, evidence of MPs in the terrestrial system cannot be disregarded. The spread, accumulation, and consumption of plastics are used as indicators to refer to an epoch: plasticene. The intricacies of microplastics and their manifold effects label them as stressors. To illustrate the effects and consequences of these harmful chemicals on human health, the most poisonous and deadly chemicals found in all plastic items are highlighted. The ubiquitous presence and its potential health hazards on marine and terrestrial ecosystems have been reviewed. It has been well-documented that aquatic organisms can ingest microplastics and transfer them tropically.&#xa0;This indicates a serious knowledge gap regarding the microplastics' ecotoxicological effects on marine organisms and higher trophic level consumers, such as humans, due to the absence of studies conducted either at amounts relevant to the environment or throughout entire ecosystems. The goal of the current review is to provide a comprehensive summary of our understanding of the types, origins, content, and detrimental consequences of microplastics on persons and the environment.</p> Graphical Abstract <p></p>