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<p>Bisphenol A (BPA) is a widely used component in plastics, BPA leaches into food and water, under conditions with pH changes or increased temperatures. This current study focuses on the evaluation BPA induced developmental toxicity in zebrafish embryos. And estimation of mangrove <i>Avicennia marina</i> (AM) and <i>Avicennia officianalis</i> (AO) leaf extracts for their nullifying properties against BPA these embryos. BPA-induced detrimental effects on embryo pigmentation and mortality are concentrations and time-dependent. The lethal concentration 50 (LC50) value for BPA was determined as 12.5&#xa0;µg/mL. Co-treatment studies with AM and AO extracts alongside BPA did not significantly nullify toxicity; however, AO showed delayed hatching and increased mortality rates compared to AM. The apoptotic assays showed the induction of neurotoxicity and reduced fluorescence in brain cells and nerves in BPA-exposed larvae. However, AM and AO extracts at 25&#xa0;µg/mL showed significant protective effects in brain cells and spinal regions akin to control. AO demonstrated superior neuroprotective effects, highlighting its potential as a nullifying agent against BPA-induced neurodegeneration. Fungal stains used, showed significant reduction in BPA present in the solution, proving its BPA degrading capabilities. Future studies could explore the molecular mechanisms underlying these effects and optimize concentrations for enhanced nullification of BPA-induced toxicity.</p> Graphical Abstract <p></p>

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Impact of Bisphenol A on Zebrafish Embryos and Mitigation Using Mangrove Botanicals

  • 期刊论文

  • 发表日期：

    2025年4月17日

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  • A. Mohamed Adnan,
  • Architha Vijayalakshmi,
  • S. Hemalatha

摘要

Bisphenol A (BPA) is a widely used component in plastics, BPA leaches into food and water, under conditions with pH changes or increased temperatures. This current study focuses on the evaluation BPA induced developmental toxicity in zebrafish embryos. And estimation of mangrove Avicennia marina (AM) and Avicennia officianalis (AO) leaf extracts for their nullifying properties against BPA these embryos. BPA-induced detrimental effects on embryo pigmentation and mortality are concentrations and time-dependent. The lethal concentration 50 (LC50) value for BPA was determined as 12.5 µg/mL. Co-treatment studies with AM and AO extracts alongside BPA did not significantly nullify toxicity; however, AO showed delayed hatching and increased mortality rates compared to AM. The apoptotic assays showed the induction of neurotoxicity and reduced fluorescence in brain cells and nerves in BPA-exposed larvae. However, AM and AO extracts at 25 µg/mL showed significant protective effects in brain cells and spinal regions akin to control. AO demonstrated superior neuroprotective effects, highlighting its potential as a nullifying agent against BPA-induced neurodegeneration. Fungal stains used, showed significant reduction in BPA present in the solution, proving its BPA degrading capabilities. Future studies could explore the molecular mechanisms underlying these effects and optimize concentrations for enhanced nullification of BPA-induced toxicity.

Graphical Abstract