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<p>Colistin is a last-resort drug useful in the treatment of infections caused by multidrug-resistant Enterobacteriaceae. However, colistin-resistant bacterial strains may occur in human and veterinary medicine. The present survey investigated the occurrence and dissemination of colistin-resistant <i>Escherichia coli</i> among yellow-legged seagulls (<i>Larus michahellis</i>). A total of 218 <i>E. coli</i> strains, previously isolated from feces of yellow-legged seagulls, were submitted to the broth microdilution test to assess colistin minimum inhibition concentration (MIC) and the isolates that were resistant were analyzed through PCR to detect mobile colistin resistance genes (<i>mcr1</i> – <i>mcr9</i>). Four (1.83%) isolates were colistin-resistant: one strain with MIC of 4&#xa0;µg/mL, 3 strains with MIC &gt; 256&#xa0;µg/mL. The nine investigated <i>mcr</i> genes were not detected in any tested strain. The detection of colistin-resistant <i>E. coli</i>, even though with low prevalence, suggested that seagulls may contribute to the spreading of bacteria resistant to this antimicrobial. Monitoring wild birds is a useful tool for assessing the spread of new antimicrobial resistance.</p>

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Occurrence of colistin-resistant Escherichia coli in yellow-legged seagulls (Larus michahellis) from Central Italy

  • 期刊论文

  • 发表日期：

    2026年6月24日

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  • Fabrizio Bertelloni,
  • Giulia Cagnoli,
  • Alessia Di Paolo,
  • Valentina Virginia Ebani

摘要

Colistin is a last-resort drug useful in the treatment of infections caused by multidrug-resistant Enterobacteriaceae. However, colistin-resistant bacterial strains may occur in human and veterinary medicine. The present survey investigated the occurrence and dissemination of colistin-resistant Escherichia coli among yellow-legged seagulls (Larus michahellis). A total of 218 E. coli strains, previously isolated from feces of yellow-legged seagulls, were submitted to the broth microdilution test to assess colistin minimum inhibition concentration (MIC) and the isolates that were resistant were analyzed through PCR to detect mobile colistin resistance genes (mcr1 – mcr9). Four (1.83%) isolates were colistin-resistant: one strain with MIC of 4 µg/mL, 3 strains with MIC > 256 µg/mL. The nine investigated mcr genes were not detected in any tested strain. The detection of colistin-resistant E. coli, even though with low prevalence, suggested that seagulls may contribute to the spreading of bacteria resistant to this antimicrobial. Monitoring wild birds is a useful tool for assessing the spread of new antimicrobial resistance.