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<p>This study assessed the impact of dietary prebiotic supplementation on broiler chickens challenged with <i>Salmonella Typhimurium</i>. In experiment I, the treatments consisted of control (K) [without supplementation]; supplemented with 0.565% autolyzed whole yeast cell (W); supplemented with 0.125% autolyzed whole yeast cell (WP); supplemented with 0.565% enzymatically removed yeast cell wall (CELL) and supplemented with 0.2% pure Mannan-oligosaccharides (MOS) + β-glucan (MB). The second experiment, the <i>Salmonella Typhimurium</i> challenge was performed on day 7 post-hatch. Birds in the CELL group in Experiment I exhibited higher final body weight and weight gain (<i>P</i> = 0.001). On day 21, jejunum villus height (VH) was lower in the MB group, while jejunum crypt depth (CD) was lower in the WP and K groups <i>(P</i> &lt; 0.05). The W group had the lowest VH and CD in the ileum (<i>P</i> &lt; 0.05). At day 35, jejunal villus health was unaffected by prebiotic supplementation, but the CELL group showed the highest VH and CD in the ileum (<i>P</i> &lt; 0.05). Gene expression analysis revealed significant differences in claudin, IL-1β, and IL-10 expressions. In experiment II, the CELL group exhibits the highest final live body weight and weight gain (<i>P</i> &lt; 0.05). Intestinal histology varied among groups and time points. Gene expression analysis indicated upregulation of claudin and occludin in certain groups, while IL-1β was upregulated in all groups and IL-10 showed varied expressions. In conclusion, prebiotic supplementation, particularly yeast cell wall, positively influenced broiler performance, intestinal histology, and gene expression related to the intestinal barrier.</p>

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Response of broiler chickens to dietary different yeast cell wall components challenged with Salmonella typhimurium

  • 期刊论文

  • 发表日期：

    2025年9月25日

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  • Pinar Sacakli,
  • Elsayed Mickdam,
  • Alev Gurol Bayraktaroglu,
  • Burcu Ekim,
  • Ozge Sizmaz

摘要

This study assessed the impact of dietary prebiotic supplementation on broiler chickens challenged with Salmonella Typhimurium. In experiment I, the treatments consisted of control (K) [without supplementation]; supplemented with 0.565% autolyzed whole yeast cell (W); supplemented with 0.125% autolyzed whole yeast cell (WP); supplemented with 0.565% enzymatically removed yeast cell wall (CELL) and supplemented with 0.2% pure Mannan-oligosaccharides (MOS) + β-glucan (MB). The second experiment, the Salmonella Typhimurium challenge was performed on day 7 post-hatch. Birds in the CELL group in Experiment I exhibited higher final body weight and weight gain (P = 0.001). On day 21, jejunum villus height (VH) was lower in the MB group, while jejunum crypt depth (CD) was lower in the WP and K groups (P < 0.05). The W group had the lowest VH and CD in the ileum (P < 0.05). At day 35, jejunal villus health was unaffected by prebiotic supplementation, but the CELL group showed the highest VH and CD in the ileum (P < 0.05). Gene expression analysis revealed significant differences in claudin, IL-1β, and IL-10 expressions. In experiment II, the CELL group exhibits the highest final live body weight and weight gain (P < 0.05). Intestinal histology varied among groups and time points. Gene expression analysis indicated upregulation of claudin and occludin in certain groups, while IL-1β was upregulated in all groups and IL-10 showed varied expressions. In conclusion, prebiotic supplementation, particularly yeast cell wall, positively influenced broiler performance, intestinal histology, and gene expression related to the intestinal barrier.