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Purpose <p>Whether racial/ethnic differences exist in time to nephrectomy (TTN) and whether prolonged TTN differentially affects cancer-specific mortality (CSM) remains unclear. We evaluated race/ethnicity as a predictor of prolonged TTN and assessed race/ethnicity-specific associations between TTN and CSM in localized renal cell carcinoma (RCC).</p> Methods <p>Patients were identified within the Surveillance, Epidemiology and End Results database (2010–2021) and stratified according to race/ethnicity and TTN ≤ 3 vs. &gt; 3 months. Multivariable logistic regression models, propensity score matching (PSM) and multivariable competing risks regression models were used.</p> Results <p>In 11,058 T1b–2 N0 M0 clear-cell RCC patients, TTN &gt; 3 months was recorded in 1168 (15.6%) of 7506 Caucasians, in 505 (23.6%) of 2138 Hispanics, in 180 (26.6%) of 676 African Americans, and in 118 (16.0%) of 738 Asians and Pacific Islanders (API). Hispanic (OR 1.80, p &lt; 0.001) and African American (OR 2.10, p &lt; 0.001) race/ethnicity independently predicted higher proportions of TTN &gt; 3 months, compared to Caucasian. Over the study span, the proportion of patients with TTN &gt; 3 months increased significantly in all four racial/ethnic groups (all p &lt; 0.01). After PSM, TTN &gt; 3 months was associated with higher CSM in Caucasians (sHR 1.57, p &lt; 0.001) and in Hispanics (sHR 1.55, p = 0.046), but not in African Americans or APIs.</p> Conclusion <p>In localized RCC patients treated with nephrectomy, TTN &gt; 3 months became more prevalent over time in all four examined racial/ethnic groups. In Hispanics and African Americans, TTN &gt; 3 months proportions were higher than in Caucasians and APIs. TTN &gt; 3 months was independently associated with higher CSM in Caucasians and Hispanics, but not in African Americans and APIs.</p>

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Racial/ethnic differences in time to nephrectomy and its association with cancer-specific mortality in localized renal cell carcinoma

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年4月16日

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  • Maximilian Filzmayer,
  • Federico Polverino,
  • Michele Petix,
  • Leonardo Quarta,
  • Filippo Orlandi,
  • Jordan A. Goyal,
  • Nicola Longo,
  • Gennaro Musi,
  • Alberto Briganti,
  • Salvatore Micali,
  • Shahrokh F. Shariat,
  • Marina Kosiba,
  • Clara Humke,
  • Mike Wenzel,
  • Fred Saad,
  • Felix K.-H. Chun,
  • Pierre I. Karakiewicz

摘要

Purpose

Whether racial/ethnic differences exist in time to nephrectomy (TTN) and whether prolonged TTN differentially affects cancer-specific mortality (CSM) remains unclear. We evaluated race/ethnicity as a predictor of prolonged TTN and assessed race/ethnicity-specific associations between TTN and CSM in localized renal cell carcinoma (RCC).

Methods

Patients were identified within the Surveillance, Epidemiology and End Results database (2010–2021) and stratified according to race/ethnicity and TTN ≤ 3 vs. > 3 months. Multivariable logistic regression models, propensity score matching (PSM) and multivariable competing risks regression models were used.

Results

In 11,058 T1b–2 N0 M0 clear-cell RCC patients, TTN > 3 months was recorded in 1168 (15.6%) of 7506 Caucasians, in 505 (23.6%) of 2138 Hispanics, in 180 (26.6%) of 676 African Americans, and in 118 (16.0%) of 738 Asians and Pacific Islanders (API). Hispanic (OR 1.80, p < 0.001) and African American (OR 2.10, p < 0.001) race/ethnicity independently predicted higher proportions of TTN > 3 months, compared to Caucasian. Over the study span, the proportion of patients with TTN > 3 months increased significantly in all four racial/ethnic groups (all p < 0.01). After PSM, TTN > 3 months was associated with higher CSM in Caucasians (sHR 1.57, p < 0.001) and in Hispanics (sHR 1.55, p = 0.046), but not in African Americans or APIs.

Conclusion

In localized RCC patients treated with nephrectomy, TTN > 3 months became more prevalent over time in all four examined racial/ethnic groups. In Hispanics and African Americans, TTN > 3 months proportions were higher than in Caucasians and APIs. TTN > 3 months was independently associated with higher CSM in Caucasians and Hispanics, but not in African Americans and APIs.