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Purpose <p>To evaluate the efficacy of long-term outcomes and compare the differences between oral mucosal grafts (OMGs) and colonic mucosal grafts (CMGs) in the treatment of complex long-segment urethral stenosis.</p> Methods <p>We conducted a retrospective analysis of patients with long-segment urethral strictures (&gt; 10&#xa0;cm) who underwent one-stage urethroplasty using either CMGs or OMGs at multiple institutions between 2000 and 2020 in China. Urethral reconstruction with CMGs was performed in 69 patients, while OMG-based urethroplasty was conducted in 225 patients. The primary measure of success was defined as normal voiding and urethrogram results without the need for any postoperative interventions, such as dilations.</p> Results <p>In the CMG group, urethroplasty procedures ranged from 11 to 21&#xa0;cm in length (mean: 17.3&#xa0;cm), achieving an overall success rate of 85.5% (59/69) with a mean follow-up duration of 145&#xa0;months (range: 20–258&#xa0;months). For the OMG group, urethroplasty lengths ranged from 11 to 20&#xa0;cm (mean: 13.6&#xa0;cm), with an overall success rate of 81.8% (184/225) and a mean follow-up duration of 58&#xa0;months (range: 13–150&#xa0;months). A key limitation of the study was the absence of tools to assess patients’ quality of life.</p> Conclusion <p>Our findings suggest that both CMGs and OMGs are excellent materials for substitution urethroplasty, with both techniques proving effective for managing severe panurethral strictures. The most common complication was meatal stenosis, particularly in patients with lichen sclerosis (LS).</p>

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A nation-wide multi-institutional evaluation of oral versus colonic mucosal grafts for the treatment of complex long-segment urethral strictures: comparative long-term outcomes and analysis of complications from China

  • 期刊论文

  • 发表日期：

    2026年2月3日

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  • Ying Liu,
  • Jing-Dong Xue,
  • Chao Li,
  • Lin-Lin Zhang,
  • Zhuo Zhang,
  • Qing-Bing Zhang,
  • Xue-Jun Huangpu,
  • Zi-Zhen Hou,
  • Hai Jiang,
  • Xiang-Guo Lv,
  • Qing-Kang Xu,
  • Zhong-Hua Liu,
  • Ying-Long Sa,
  • Yue-Min Xu,
  • Chao Feng

摘要

Purpose

To evaluate the efficacy of long-term outcomes and compare the differences between oral mucosal grafts (OMGs) and colonic mucosal grafts (CMGs) in the treatment of complex long-segment urethral stenosis.

Methods

We conducted a retrospective analysis of patients with long-segment urethral strictures (> 10 cm) who underwent one-stage urethroplasty using either CMGs or OMGs at multiple institutions between 2000 and 2020 in China. Urethral reconstruction with CMGs was performed in 69 patients, while OMG-based urethroplasty was conducted in 225 patients. The primary measure of success was defined as normal voiding and urethrogram results without the need for any postoperative interventions, such as dilations.

Results

In the CMG group, urethroplasty procedures ranged from 11 to 21 cm in length (mean: 17.3 cm), achieving an overall success rate of 85.5% (59/69) with a mean follow-up duration of 145 months (range: 20–258 months). For the OMG group, urethroplasty lengths ranged from 11 to 20 cm (mean: 13.6 cm), with an overall success rate of 81.8% (184/225) and a mean follow-up duration of 58 months (range: 13–150 months). A key limitation of the study was the absence of tools to assess patients’ quality of life.

Conclusion

Our findings suggest that both CMGs and OMGs are excellent materials for substitution urethroplasty, with both techniques proving effective for managing severe panurethral strictures. The most common complication was meatal stenosis, particularly in patients with lichen sclerosis (LS).