Scholarlink

Purpose <p>To investigate the association between systemic inflammation and activities of daily living (ADL) in older patients with chronic kidney disease (CKD) in the acute phase.</p> Methods <p>This observational, retrospective cohort study included patients with CKD aged 65&#xa0;years and older with unscheduled admissions to the nephrology department between January 2019 and February 2022. Patients who underwent maintenance hemodialysis therapy; died during hospitalization; were treated in other departments; experienced serious events during hospitalization; or did not receive rehabilitation during hospitalization were excluded. Systemic inflammation was assessed by the modified Glasgow Prognostic Score (mGPS) on admission, and ADL was assessed by functional independence measure (FIM) at discharge.</p> Results <p>A total of 89 patients (median age, 80&#xa0;years [interquartile range, 75–84&#xa0;years]) were included in the analysis. An mGPS score of 0, 1, and 2 was assigned to 41 (46.1%), 15 (16.9%), and 33 (37.1%) patients, respectively. In multivariable analysis, the mGPS (SE = 2.16; β =  − 0.25; <i>P</i> = 0.001) was significantly associated with the FIM score at discharge. On the other hand, albumin (<i>ρ</i> = 0.093; 95% CI, − 0.12 to 0.30; <i>P</i> = 0.384) and CRP level (<i>ρ</i> =  − 0.176; 95% CI; − 0.37 to 0.03; <i>P</i> = 0.098) were not significantly correlated with the FIM score at discharge.</p> Conclusion <p>Among older patients with CKD in the acute phase, systemic inflammation assessed using the mGPS may be useful for predicting ADL.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Systemic inflammation is associated with reduced functional recovery in older inpatients with chronic kidney disease

  • 期刊论文

  • 发表日期：

    2025年8月21日

查看全文
  • Keita Ohashi,
  • Kentaro Iwata,
  • Kanji Yamada,
  • Yoshihiro Yoshimura,
  • Atsuki Nozaki,
  • Akio Yamamoto,
  • Kumiko Ono,
  • Takeshi Kitai,
  • Akihiro Yoshimoto,
  • Nobuo Kohara,
  • Akira Ishikawa

摘要

Purpose

To investigate the association between systemic inflammation and activities of daily living (ADL) in older patients with chronic kidney disease (CKD) in the acute phase.

Methods

This observational, retrospective cohort study included patients with CKD aged 65 years and older with unscheduled admissions to the nephrology department between January 2019 and February 2022. Patients who underwent maintenance hemodialysis therapy; died during hospitalization; were treated in other departments; experienced serious events during hospitalization; or did not receive rehabilitation during hospitalization were excluded. Systemic inflammation was assessed by the modified Glasgow Prognostic Score (mGPS) on admission, and ADL was assessed by functional independence measure (FIM) at discharge.

Results

A total of 89 patients (median age, 80 years [interquartile range, 75–84 years]) were included in the analysis. An mGPS score of 0, 1, and 2 was assigned to 41 (46.1%), 15 (16.9%), and 33 (37.1%) patients, respectively. In multivariable analysis, the mGPS (SE = 2.16; β =  − 0.25; P = 0.001) was significantly associated with the FIM score at discharge. On the other hand, albumin (ρ = 0.093; 95% CI, − 0.12 to 0.30; P = 0.384) and CRP level (ρ =  − 0.176; 95% CI; − 0.37 to 0.03; P = 0.098) were not significantly correlated with the FIM score at discharge.

Conclusion

Among older patients with CKD in the acute phase, systemic inflammation assessed using the mGPS may be useful for predicting ADL.