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<p>This trial tested the effects of <i>Houttuynia cordata</i> (HC) feeding on lactation performance, redox status, and inflammatory response of heat stress (HS)-suffered dairy cows. Twenty dairy cows were assigned into two dietary treatments, which were offered a basal TMR diet or a diet containing 2% HC for a 35-day trial, during which the average temperature and humidity index was 76.57 ± 0.22 (&gt; 72), indicating a possible exposure to HS. The results showed that HC intake reduced the respiratory rate and rectal temperature, elevated the milk yield, and increased the concentrations of glucose, total phenolic compounds, and total flavonoids and catalase activity in serum of HS-suffered cows (<i>p</i> &lt; 0.05). HC consumption reduced serum insulin, malondialdehyde, diamine oxidase activity, and lipopolysaccharides concentration, as well as lipopolysaccharide-binding protein and interleukin-1β concentrations in the serum and milk of cows. (<i>p</i> &lt; 0.05). Plasma metabolome demonstrated that HC intake increased the concentrations of microbial tryptophan catabolites and reduced the levels of acylcarnitine (<i>p</i> &lt; 0.05). Fecal microbiota sequencing showed that HC ingestion elevated the microbial alpha diversity, indicative of higher Chao1, Shannon, and observed species in feces of cows (<i>p</i> &lt; 0.05). Dietary HC inclusion altered the abundances of certain taxa, like phylum <i>Verrucomicrobiota</i> and genus <i>Akkermansia</i>, in feces of dairy cows (<i>p</i> &lt; 0.05). Network analysis indicated that long-chain acylcarnitines were negatively correlated with <i>Prevotellaceae_UCG-004</i> and <i>Akkermansia</i> (<i>p</i> &lt; 0.05). Overall, HC intake alleviated thermal stress-induced performance impairment, redox imbalance, and inflammation, possibly via altering fecal microbiome and plasma metabolite profile in cows.</p>

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Dietary Houttuynia cordata Thunb attenuates redox imbalance and inflammation possibly induced by heat stress in dairy cows associated with altered fecal microbiota and metabolomics profile

  • 期刊论文

  • 发表日期：

    2025年12月2日

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  • Lunjie Feng,
  • Hongyu Yi,
  • Zhaoxi Xie,
  • Pan Zhou,
  • Yong Zhang,
  • Ling Cheng,
  • Shuai Chen,
  • Liwen Chen,
  • Chengquan Jiang,
  • Hui Diao,
  • Honglin Yan

摘要

This trial tested the effects of Houttuynia cordata (HC) feeding on lactation performance, redox status, and inflammatory response of heat stress (HS)-suffered dairy cows. Twenty dairy cows were assigned into two dietary treatments, which were offered a basal TMR diet or a diet containing 2% HC for a 35-day trial, during which the average temperature and humidity index was 76.57 ± 0.22 (> 72), indicating a possible exposure to HS. The results showed that HC intake reduced the respiratory rate and rectal temperature, elevated the milk yield, and increased the concentrations of glucose, total phenolic compounds, and total flavonoids and catalase activity in serum of HS-suffered cows (p < 0.05). HC consumption reduced serum insulin, malondialdehyde, diamine oxidase activity, and lipopolysaccharides concentration, as well as lipopolysaccharide-binding protein and interleukin-1β concentrations in the serum and milk of cows. (p < 0.05). Plasma metabolome demonstrated that HC intake increased the concentrations of microbial tryptophan catabolites and reduced the levels of acylcarnitine (p < 0.05). Fecal microbiota sequencing showed that HC ingestion elevated the microbial alpha diversity, indicative of higher Chao1, Shannon, and observed species in feces of cows (p < 0.05). Dietary HC inclusion altered the abundances of certain taxa, like phylum Verrucomicrobiota and genus Akkermansia, in feces of dairy cows (p < 0.05). Network analysis indicated that long-chain acylcarnitines were negatively correlated with Prevotellaceae_UCG-004 and Akkermansia (p < 0.05). Overall, HC intake alleviated thermal stress-induced performance impairment, redox imbalance, and inflammation, possibly via altering fecal microbiome and plasma metabolite profile in cows.