Scholarlink

<p>This study evaluated the effectiveness of antibiotic, probiotic, and antimicrobial peptide (AMP) supplements in mitigating adverse consequences of necrotic enteritis (NE) in broilers. In total, 720 one-day-old (Ross-308) male&#xa0;broiler chicks were randomly assigned to five distinct feeding regimens (each treatment consisting of six replicates&#xa0;of 24&#xa0;birds) including: (1) negative control (NC), fed only basal diet; (2) positive control (PC); with <i>C. perfringens</i> challenge + basal diet; (3) CP-Ab: challenged + virginiamycin (Stafac® 500) at 200&#xa0;g/ton, (4) CP-Pro: challenged + 200&#xa0;g/ton <i>B. subtilis</i> PB6 (Clostat dry®) probiotic additive, and (5) CP-LS2: challenged and fed an antimicrobial peptide (LassoTide Plus®) at 200&#xa0;g/ton. The NE challenge was induced by administering 10X coccidia vaccine on day 15 followed by inoculation with a pathogenic field strain of <i>C</i>. <i>perfringens</i> type G (1 × 10<sup>8</sup>&#xa0;CFU/ml/ bird; 1&#xa0;ml) on days 19 and 20 through oral gavage. Feeding AMP and probiotic to the&#xa0;NE-affected broilers&#xa0;resulted in 23.93% and 19.70% respectively higher body weight gain and 76.59% and 70.27% lower mortality compared to the PC. Similarly, supplementation with AMP improved (<i>P &lt;</i> 0.05) gut morphology, carcass yield (5.82%), meat water holding capacity (14.73%), and reduced cooking loss (10.01%), dripping loss (20.87%), and shear force (25%) as compared to the PC. Additionally, the excreta score, litter quality and welfare attributes were significantly ameliorated (<i>P &lt;</i> 0.05) with AMP addition. In conclusion, the findings suggest that AMP outperformed both virginiamycin and probiotic, demonstrating its potential as a superior substitute for AGPs in broilers.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Effects of replacing antibiotics with probiotics and antimicrobial peptides on performance, gut health, carcass traits, meat quality, and welfare in broilers infected with Eimeria and Clostridium perfringens

  • 期刊论文

  • 发表日期：

    2025年4月24日

查看全文
  • Muhammad Muneeb,
  • Ehsaan Ullah Khan,
  • Mubashar Ali,
  • Muhammad Suleman,
  • Muhammad Shabir Shaheen,
  • Muhammad Shahbaz Zafar,
  • Sohail Ahmad

摘要

This study evaluated the effectiveness of antibiotic, probiotic, and antimicrobial peptide (AMP) supplements in mitigating adverse consequences of necrotic enteritis (NE) in broilers. In total, 720 one-day-old (Ross-308) male broiler chicks were randomly assigned to five distinct feeding regimens (each treatment consisting of six replicates of 24 birds) including: (1) negative control (NC), fed only basal diet; (2) positive control (PC); with C. perfringens challenge + basal diet; (3) CP-Ab: challenged + virginiamycin (Stafac® 500) at 200 g/ton, (4) CP-Pro: challenged + 200 g/ton B. subtilis PB6 (Clostat dry®) probiotic additive, and (5) CP-LS2: challenged and fed an antimicrobial peptide (LassoTide Plus®) at 200 g/ton. The NE challenge was induced by administering 10X coccidia vaccine on day 15 followed by inoculation with a pathogenic field strain of C. perfringens type G (1 × 108 CFU/ml/ bird; 1 ml) on days 19 and 20 through oral gavage. Feeding AMP and probiotic to the NE-affected broilers resulted in 23.93% and 19.70% respectively higher body weight gain and 76.59% and 70.27% lower mortality compared to the PC. Similarly, supplementation with AMP improved (P < 0.05) gut morphology, carcass yield (5.82%), meat water holding capacity (14.73%), and reduced cooking loss (10.01%), dripping loss (20.87%), and shear force (25%) as compared to the PC. Additionally, the excreta score, litter quality and welfare attributes were significantly ameliorated (P < 0.05) with AMP addition. In conclusion, the findings suggest that AMP outperformed both virginiamycin and probiotic, demonstrating its potential as a superior substitute for AGPs in broilers.