<p>This study investigates the sliding wear and electrochemical corrosion behaviors of single-crystal copper with (100), (110), and (111) orientations under different loading and frequency conditions. A multifunctional friction and wear tester, an electrochemical workstation, and a scanning electron microscope were employed to observe worn and corroded morphology and to explore the wear and corrosion mechanisms. The experimental results indicate that crystal orientation significantly influences the wear and corrosion resistance of single-crystal copper. The Cu (111) surface, characterized by its high atomic density, exhibits low adhesion and relatively good wear resistance. In contrast, Cu (110) has a lower hardness, a larger wear volume, more severe surface damage, and inferior wear resistance. The wear morphology of Cu (100) is less pronounced, while Cu (111) experiences enhanced wear at higher frequencies. Electrochemical tests revealed that the E_corr followed the order (110) &gt; (100) &gt; (111), with a negative shift of 18.97&#xa0;mV in the polarization curve. The I_corr increased by approximately 0.93 times.</p>