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<p>This study developed a planar binuclear Cd(II) acylhydrazone Schiff base complex as a novel DNA-targeted anti-tumour agent. The complex was synthesised via a one-pot reaction of the ligand HL with cadmium nitrate. X-ray crystallography revealed a centrosymmetric structure, with each Cd(II) ion in a seven-coordinate geometry, forming a rigid planar system through phenoxide bridging. Spectroscopic analyses confirmed ligand-to-ligand charge transfer fluorescence with a lifetime of 5.746 ns, attributed to enhanced rigidity upon coordination. DNA binding studies demonstrated that the complex intercalates strongly into CT-DNA, with a high binding constant (Kb = 4.85 × 10<sup>5</sup>&#xa0;M<sup>-1</sup>), significantly greater than that of the free ligand. In vitro assays showed the complex exhibits potent, concentration-dependent anti-proliferative activity against A549 and MCF-7 cancer cells (IC<sub>50</sub> = 10.88 µM and 5.28 µM, respectively), effectively inducing apoptosis, unlike the weak ligand. This planar binuclear Cd(II) complex is a promising candidate for the development of new metal-based anticancer drugs.</p>

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A planar binuclear Cadmium(II)-Acylhydrazone Schiff base complex as a potent DNA-targeted anticancer agent

  • 期刊论文

  • 发表日期：

    2026年6月29日

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  • Jun Wang,
  • Peiyu Peng,
  • Xuexue Pan,
  • Wenhua Zhao,
  • Qamar Abbas

摘要

This study developed a planar binuclear Cd(II) acylhydrazone Schiff base complex as a novel DNA-targeted anti-tumour agent. The complex was synthesised via a one-pot reaction of the ligand HL with cadmium nitrate. X-ray crystallography revealed a centrosymmetric structure, with each Cd(II) ion in a seven-coordinate geometry, forming a rigid planar system through phenoxide bridging. Spectroscopic analyses confirmed ligand-to-ligand charge transfer fluorescence with a lifetime of 5.746 ns, attributed to enhanced rigidity upon coordination. DNA binding studies demonstrated that the complex intercalates strongly into CT-DNA, with a high binding constant (Kb = 4.85 × 105 M-1), significantly greater than that of the free ligand. In vitro assays showed the complex exhibits potent, concentration-dependent anti-proliferative activity against A549 and MCF-7 cancer cells (IC50 = 10.88 µM and 5.28 µM, respectively), effectively inducing apoptosis, unlike the weak ligand. This planar binuclear Cd(II) complex is a promising candidate for the development of new metal-based anticancer drugs.