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<p>A new Ni<sup>II</sup> two-dimensional coordination polymer [Ni<sub>2</sub>(CN<sub>2</sub>N)<sub>2</sub><b>L</b>]<sub><i>n</i></sub> (<b>1</b>) is rendered assimilating the metal salt, Ni(ClO<sub>4</sub>)<sub>2</sub><b>·</b>6H<sub>2</sub>O, H<sub>2</sub>L [<i>N</i>,<i>N</i>′-bis(3-methoxysalicylidenimino)-1,3-diaminopropane] and the co-ligand, sodium dicyanamide [NaN(CN)<sub>2</sub>]. In the asymmetric unit, one Ni<sup>II</sup> ion belongs on a distorted octahedral framework, whereas, the distorted tetrahedral geometry is procured by the other Ni<sup>II</sup> ion. The two CN<sub>2</sub>N<sup>2−</sup> anions bridge between nickel centers in adjacent molecules resulting in the formation of a two-dimensional coordination polymer with a (6<sup>3</sup>) topology. The magneto-structural concurrence with variation of temperature (T) divulges that a weak anti-ferromagnetic interaction endures between two adjacent Ni<sup>II</sup> centers where the χ<sub><i>M</i></sub><i>T</i> value is 1.20 cm<sup>3</sup>&#xa0;mol<sup>−1</sup>&#xa0;K. The electrochemical study is implemented that manifests the redox peaks concerning the reduction and oxidation potentials of Ni(II) system. Furthermore, complex <b>1</b> impedes the cell growth of human colorectal carcinoma cells (COLO 205 cells), human lung carcinoma cells (A549 cells), and human hepatocellular carcinoma cells (PLC5 cells). In human colorectal carcinoma cells (COLO 205 cells), the highest inhibitory activity with 46.00 ± 1.09&#xa0;μM IC<sub>50</sub> is revealed.</p>

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Synthesis, structural aspects and inhibitory effect on carcinoma cells of schiff base incorporated a dicyanamide and phenoxide bridged Ni(II) two-dimensional coordination polymer

  • 期刊论文

  • 发表日期：

    2025年7月15日

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  • Kuheli Das,
  • Amitabha Datta

摘要

A new NiII two-dimensional coordination polymer [Ni2(CN2N)2L]n (1) is rendered assimilating the metal salt, Ni(ClO4)2·6H2O, H2L [N,N′-bis(3-methoxysalicylidenimino)-1,3-diaminopropane] and the co-ligand, sodium dicyanamide [NaN(CN)2]. In the asymmetric unit, one NiII ion belongs on a distorted octahedral framework, whereas, the distorted tetrahedral geometry is procured by the other NiII ion. The two CN2N2− anions bridge between nickel centers in adjacent molecules resulting in the formation of a two-dimensional coordination polymer with a (63) topology. The magneto-structural concurrence with variation of temperature (T) divulges that a weak anti-ferromagnetic interaction endures between two adjacent NiII centers where the χMT value is 1.20 cm3 mol−1 K. The electrochemical study is implemented that manifests the redox peaks concerning the reduction and oxidation potentials of Ni(II) system. Furthermore, complex 1 impedes the cell growth of human colorectal carcinoma cells (COLO 205 cells), human lung carcinoma cells (A549 cells), and human hepatocellular carcinoma cells (PLC5 cells). In human colorectal carcinoma cells (COLO 205 cells), the highest inhibitory activity with 46.00 ± 1.09 μM IC50 is revealed.