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<p>Complexes (<b>1</b>–<b>3</b>) with nitrogen-based heterocyclic ligands were synthesized by reacting ruthenium precursor [Ru(η<sup>6</sup>-<i>p</i>-cymene)(<i>μ</i>-Cl)Cl]<sub>2</sub> and ligands <b>L1</b>, <b>L2</b> and <b>L3</b>. Upon reacting the complexes <b>1</b>–<b>3</b> with sodium azide, azido complexes <b>4</b>–<b>6</b> were obtained. These complexes as well as ligands were tested for anti-cancer activity where, ligand <b>L2</b> was found to have lowest IC<sub>50</sub> value with stable interaction of ROCK-1 protein suggesting one of the possible mechanisms for complex’s anti-cancer activity.</p> Graphical Abstract <p>Half-sandwich ruthenium complexes <b>1</b>–<b>3</b> were synthesized and upon further reaction with sodium azide (NaN3) in methanol yielded azido ruthenium complexes <b>4</b>–<b>6</b>. All the ligands and complexes were studied for anticancer activity. Anticancer activity assessed in human lung cancer cell line (A549) revealed that ligand <b>L2</b> has the highest anti-cancer activity amongst the others studied.</p>

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Ruthenium complexes comprising nitrogen donor ligands: synthesis and investigation of their cytotoxicity potential

  • 期刊论文

  • 发表日期：

    2025年5月2日

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  • Lathewdeipor Shadap,
  • Charlestine Soh,
  • Smarling Suting,
  • Mayuri Bhattacharyya,
  • Baphilinia Jones Mylliemngap,
  • Suktilang Majaw,
  • Werner Kaminsky,
  • Kenneth Umdor,
  • Cheerfulman Masharing,
  • Badaker M. Laloo,
  • Barisha Wahlang,
  • Matbiangthew Shadap,
  • Evergreen K. Rymmai

摘要

Complexes (1–3) with nitrogen-based heterocyclic ligands were synthesized by reacting ruthenium precursor [Ru(η6-p-cymene)(μ-Cl)Cl]2 and ligands L1, L2 and L3. Upon reacting the complexes 1–3 with sodium azide, azido complexes 4–6 were obtained. These complexes as well as ligands were tested for anti-cancer activity where, ligand L2 was found to have lowest IC50 value with stable interaction of ROCK-1 protein suggesting one of the possible mechanisms for complex’s anti-cancer activity.

Graphical Abstract

Half-sandwich ruthenium complexes 1–3 were synthesized and upon further reaction with sodium azide (NaN3) in methanol yielded azido ruthenium complexes 4–6. All the ligands and complexes were studied for anticancer activity. Anticancer activity assessed in human lung cancer cell line (A549) revealed that ligand L2 has the highest anti-cancer activity amongst the others studied.