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<p>It has been shown that sonochemical treatment in the process of Lidocaine oxidation leads to an increase in the yield of Lidocaine N-oxide (LNO) while reducing the reaction time. An ADME (absorption, distribution, metabolism, and excretion) analysis of Lidocaine and LNO was performed. According to in silico calculated ADME profile, LNO is characterized by high bioavailability, efficient absorption in the gastrointestinal tract, and slight inhibition of cytochrome P450, which is a sign of low interaction with other drugs. According to the results of the analysis of LNO interaction with the mutant p53 protein by the molecular docking method, the anticancer activity of this substance can be expected.</p>

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Sonochemical Preparation of Lidocaine N-Oxide and Its Pharmacokinetic Profile

  • 期刊论文

  • 发表日期：

    2025年9月1日

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  • P. Jehani,
  • D. Gautam,
  • M. Kumar,
  • M. Panchal,
  • P. Gautam,
  • R. K. Bera

摘要

It has been shown that sonochemical treatment in the process of Lidocaine oxidation leads to an increase in the yield of Lidocaine N-oxide (LNO) while reducing the reaction time. An ADME (absorption, distribution, metabolism, and excretion) analysis of Lidocaine and LNO was performed. According to in silico calculated ADME profile, LNO is characterized by high bioavailability, efficient absorption in the gastrointestinal tract, and slight inhibition of cytochrome P450, which is a sign of low interaction with other drugs. According to the results of the analysis of LNO interaction with the mutant p53 protein by the molecular docking method, the anticancer activity of this substance can be expected.