<p>Empiricism is associated with the epistemic privileging of sensory experience. Modern science is based on experiment and observation, but it is highly revisionary of the manifest image, and does not epistemically privilege the human senses. Yet many scientists characterise themselves as empiricists, and many empiricists in philosophy take science to be the ultimate form of rational enquiry. This apparent paradox is resolved by formulating empiricism scientifically so that it epistemically privileges data, not the contents of human sensory experience (sense-data). This scientific way of understanding empiricism maintains its most important positive and negative components, and unifies it with materialism. It also unifies it with ontic structural realism, because scientific empiricism requires a minimal metaphysics of modality.</p>