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<p>The Nobel Prize of Physiology or Medicine 2025 was awarded jointly to Mary E. Brunkow, Frederick J. Ramsdell and Shimon Sakaguchi for their discoveries identifying regulatory T cells (Treg) controlling our immune system response to substances from outside and inside the body, maintaining the peripherial immune tolerance. Their discoveries encourage the development of medical treatments for cancer and autoimmune diseases. Author summarizes the immunosuppresive therapy of autoimmun hepatitis, emphasizing the importance of maintained Treg function, rather then a generalized immunsuppression.</p>

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Restoring immune tolerance in autoimmune hepatitis: therapeutic implications of the 2025 Nobel prize discoveries

  • 期刊论文

  • 发表日期：

    2026年1月30日

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  • Krisztina Hagymási

摘要

The Nobel Prize of Physiology or Medicine 2025 was awarded jointly to Mary E. Brunkow, Frederick J. Ramsdell and Shimon Sakaguchi for their discoveries identifying regulatory T cells (Treg) controlling our immune system response to substances from outside and inside the body, maintaining the peripherial immune tolerance. Their discoveries encourage the development of medical treatments for cancer and autoimmune diseases. Author summarizes the immunosuppresive therapy of autoimmun hepatitis, emphasizing the importance of maintained Treg function, rather then a generalized immunsuppression.