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<p>In recent years, the global challenge has been significant due to the rapid spread of the Covid-19 pandemic and the exponential increase in SARS-CoV-2 cases, coupled with the increase in global mortality rates. Despite efforts to contain the pandemic, timely diagnosis remains crucial to halt its progression. This work addresses the development of a multimode plasmonic refractive index (MMRI) optical biosensor based on a complementary split ring resonator (CSRR) with high sensitivity for the detection of SARS-CoV-2. The biosensor developed using the Finite Difference Time Domain Numerical Solution (FDTD) method and the analysis revealed the presence of four resonance modes in the reflection spectrum in wavelength ranges of 1500&#xa0;nm to 3500&#xa0;nm. The proposed configuration is used in the field of metamaterials, with a focus on analyzing specific sensitive dimensional parameters to optimize their performance. Research has shown that the unique interaction of light with gold and silver materials results in tunable resonance properties. These materials can be used as promising platforms for the development of a multimode optical biosensor with plasmonic refractive index for biological testing. The obtained results indicate that the designed optical biosensor has high sensitivity 1506.7&#xa0;nm/RIU, 1135.8&#xa0;nm/RIU, 803.79&#xa0;nm/RIU, and 675.45&#xa0;nm/RIU in its four resonance modes. Also, acceptable figure of merit (FOM) of 9.21, 6.4, 8.08, 6.65 are obtained for all four resonance modes, respectively. It is noteworthy that the first mode has the highest sensitivity and FOM with values ​​of 1506.8&#xa0;nm/RIU and 9.21 RIU-1, respectively.</p>

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Development of a Highly Sensitive Multimodal Plasmonic Optical Biosensor Based on a Complementary Split Ring Resonator for Detection of SARS-CoV-2

  • 期刊论文

  • 发表日期：

    2026年4月30日

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  • Ali Khodaie,
  • Hamid Heidarzadeh

摘要

In recent years, the global challenge has been significant due to the rapid spread of the Covid-19 pandemic and the exponential increase in SARS-CoV-2 cases, coupled with the increase in global mortality rates. Despite efforts to contain the pandemic, timely diagnosis remains crucial to halt its progression. This work addresses the development of a multimode plasmonic refractive index (MMRI) optical biosensor based on a complementary split ring resonator (CSRR) with high sensitivity for the detection of SARS-CoV-2. The biosensor developed using the Finite Difference Time Domain Numerical Solution (FDTD) method and the analysis revealed the presence of four resonance modes in the reflection spectrum in wavelength ranges of 1500 nm to 3500 nm. The proposed configuration is used in the field of metamaterials, with a focus on analyzing specific sensitive dimensional parameters to optimize their performance. Research has shown that the unique interaction of light with gold and silver materials results in tunable resonance properties. These materials can be used as promising platforms for the development of a multimode optical biosensor with plasmonic refractive index for biological testing. The obtained results indicate that the designed optical biosensor has high sensitivity 1506.7 nm/RIU, 1135.8 nm/RIU, 803.79 nm/RIU, and 675.45 nm/RIU in its four resonance modes. Also, acceptable figure of merit (FOM) of 9.21, 6.4, 8.08, 6.65 are obtained for all four resonance modes, respectively. It is noteworthy that the first mode has the highest sensitivity and FOM with values ​​of 1506.8 nm/RIU and 9.21 RIU-1, respectively.