Scholarlink

<p>This study explores the potential of a dielectrically modulated ferroelectric-based dual-material gate junctionless In<sub>0.3</sub>Ga<sub>0.7</sub>As/GaAs FET (DM-Ferro-DMG-JLFET) as a biosensor for detecting breast cancer biomarkers, including MDA-MB-231, Hs578T, T47D, and MCF-7, as well as the normal cell line MCF-10&#xa0;A. Incorporating a SiO<sub>2</sub>:Ferro thin layer at the control gate enhances ON-state sensitivity by exploiting variations in the dielectric constant of different biomarkers. Compared to reference structures, the proposed device achieves ON-state current sensitivity up to 48.52% and selectivity up to 45.05% for T47D. The Pearson correlation coefficient of 0.996 confirms strong linearity. Simulations under varying biomolecular charge densities show over 7.9% current reduction for T47D cells, outperforming air-filled cavities. Additionally, analog/RF figures of merit such as transconductance gain, GBW, and TFP show significant improvements. The results highlight the DM-Ferro-DMG-JLFET’s superior sensitivity and its promise for future breast cancer biosensing applications in both research and clinical diagnostics.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Ferroelectric In0.3Ga0.7As/GaAs JL-FET Based-Biosensor with Dual-material Gate Technique: Optimizing ON-State Sensitivity for Breast Cancer Cell Types Detection

  • 期刊论文

  • 发表日期：

    2026年3月31日

查看全文
  • Maryam Shaveisi,
  • Mohammad Fallahnejad,
  • Mahdi Vadizadeh

摘要

This study explores the potential of a dielectrically modulated ferroelectric-based dual-material gate junctionless In0.3Ga0.7As/GaAs FET (DM-Ferro-DMG-JLFET) as a biosensor for detecting breast cancer biomarkers, including MDA-MB-231, Hs578T, T47D, and MCF-7, as well as the normal cell line MCF-10 A. Incorporating a SiO2:Ferro thin layer at the control gate enhances ON-state sensitivity by exploiting variations in the dielectric constant of different biomarkers. Compared to reference structures, the proposed device achieves ON-state current sensitivity up to 48.52% and selectivity up to 45.05% for T47D. The Pearson correlation coefficient of 0.996 confirms strong linearity. Simulations under varying biomolecular charge densities show over 7.9% current reduction for T47D cells, outperforming air-filled cavities. Additionally, analog/RF figures of merit such as transconductance gain, GBW, and TFP show significant improvements. The results highlight the DM-Ferro-DMG-JLFET’s superior sensitivity and its promise for future breast cancer biosensing applications in both research and clinical diagnostics.