Scholarlink

<p>This study introduces a compact device for detecting changes in optical properties when a sample interacts with an analyte. We propose a cubic periodic array with four U-shaped arms made from VO₂. The sensing operation is activated when the resonance wavelength shifts caused by variations in the refractive index of analytes, driven by the phase transition of VO₂. The finite element method is used to simulate the sensor for detectiing gases, liquids, and cancer cells compared to their normal counterparts, in the mid-infrared wavelength range of 1 to 5&#xa0;μm. Following optimization of the design parameters, the sensor exhibits the highest detection wavelength sensitivities, reaching 8000&#xa0;nm/RIU for gas and 2857&#xa0;nm/RIU for liquid. Notably, the maximum quality factor of 201.8 is achieved at the resonance peak wavelength of 2295&#xa0;nm for MDA-MB-231 cancer cell, while the highest wavelength sensitivity of 3928.57&#xa0;nm/RIU is obtained for Jurkat cancer cell.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Design of a Highly Sensitive Biosensor Based on VO2 for Cancer Detection

  • 期刊论文

  • 发表日期：

    2026年2月25日

查看全文
  • Fatemeh Mohammadi Amaleh,
  • Gholamreza Honarasa,
  • Erfan Kadivar

摘要

This study introduces a compact device for detecting changes in optical properties when a sample interacts with an analyte. We propose a cubic periodic array with four U-shaped arms made from VO₂. The sensing operation is activated when the resonance wavelength shifts caused by variations in the refractive index of analytes, driven by the phase transition of VO₂. The finite element method is used to simulate the sensor for detectiing gases, liquids, and cancer cells compared to their normal counterparts, in the mid-infrared wavelength range of 1 to 5 μm. Following optimization of the design parameters, the sensor exhibits the highest detection wavelength sensitivities, reaching 8000 nm/RIU for gas and 2857 nm/RIU for liquid. Notably, the maximum quality factor of 201.8 is achieved at the resonance peak wavelength of 2295 nm for MDA-MB-231 cancer cell, while the highest wavelength sensitivity of 3928.57 nm/RIU is obtained for Jurkat cancer cell.