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<p>This work presents a novel cerium fluoride (CeF₃) and MXene-based surface plasmon resonance (SPR) sensor for detecting basal cells. Plasmonic metal silver is deposited on a BK7 prism, with an operating wavelength of 633&#xa0;nm, and the angle interrogation method is employed. Computational analysis has been carried out, and the sensing performance has been evaluated, yielding a figure of merit (FoM) of 38.538 RIU⁻¹, a maximum sensitivity of 181.9 deg/RIU, and a detection accuracy (DA) of 0.211 deg. The sensor’s performance was also assessed over a wide refractive index (RI) range of 1.33–1.40, with the highest sensitivity obtained being 230 deg/RIU. The incorporation of CeF₃ and MXene layers significantly enhances the key performance parameters compared to conventional sensors, offering a promising platform for advanced medical diagnostics.</p>

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Performance Enhancement of an Optical SPR Sensor for the Detection of Cancerous Basal Cells

  • 期刊论文

  • 发表日期：

    2026年1月3日

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  • Arun Uniyal,
  • Archana Yadav,
  • Vipin Sharma,
  • Priyanka Dobhal Uniyal,
  • D. K. Dwivedi

摘要

This work presents a novel cerium fluoride (CeF₃) and MXene-based surface plasmon resonance (SPR) sensor for detecting basal cells. Plasmonic metal silver is deposited on a BK7 prism, with an operating wavelength of 633 nm, and the angle interrogation method is employed. Computational analysis has been carried out, and the sensing performance has been evaluated, yielding a figure of merit (FoM) of 38.538 RIU⁻¹, a maximum sensitivity of 181.9 deg/RIU, and a detection accuracy (DA) of 0.211 deg. The sensor’s performance was also assessed over a wide refractive index (RI) range of 1.33–1.40, with the highest sensitivity obtained being 230 deg/RIU. The incorporation of CeF₃ and MXene layers significantly enhances the key performance parameters compared to conventional sensors, offering a promising platform for advanced medical diagnostics.