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<p>Plasmonic Photonic Crystal Fiber (PCF) sensor has established a significant impact in the biomedical industry due to its capability of real-time monitoring with high sensitivity. This study proposes an efficient gold-coated dual-channel PCF sensor and its systematic geometrical investigation to detect six distinct types of cancer cells impacting various organs within the human body. The sensor achieves maximum wavelength sensitivity of 7928.57&#xa0;nm/RIU and minimum wavelength resolution of 1.26 × 10<sup>− 5</sup> for the detection of MCF-7 breast cancer cells. The sensor outperforms by providing a significant maximum Amplitude Sensitivity (AS) of -2856.7 RIU<sup>− 1</sup> and minimum amplitude resolution of 3.5 × 10<sup>− 6</sup> in the detection of MCF-7 cells, while the highest recorded Figure of Merit (FOM) is 282 RIU<sup>− 1</sup> for MDA-MB-231 cells. The proposed sensor could prove to be an incredible photonic device that advances healthcare diagnostics and reduces mortality rates by facilitating the early identification of various cancerous cells.</p>

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Design and Analysis of Dual Channel PCF-SPR Biosensor for Multiple Cancerous Cells Detection in Human Body

  • 期刊论文

  • 发表日期：

    2025年11月6日

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  • Pratima Malhotra,
  • Surinder Singh

摘要

Plasmonic Photonic Crystal Fiber (PCF) sensor has established a significant impact in the biomedical industry due to its capability of real-time monitoring with high sensitivity. This study proposes an efficient gold-coated dual-channel PCF sensor and its systematic geometrical investigation to detect six distinct types of cancer cells impacting various organs within the human body. The sensor achieves maximum wavelength sensitivity of 7928.57 nm/RIU and minimum wavelength resolution of 1.26 × 10− 5 for the detection of MCF-7 breast cancer cells. The sensor outperforms by providing a significant maximum Amplitude Sensitivity (AS) of -2856.7 RIU− 1 and minimum amplitude resolution of 3.5 × 10− 6 in the detection of MCF-7 cells, while the highest recorded Figure of Merit (FOM) is 282 RIU− 1 for MDA-MB-231 cells. The proposed sensor could prove to be an incredible photonic device that advances healthcare diagnostics and reduces mortality rates by facilitating the early identification of various cancerous cells.