Scholarlink

<p>Bovine serum albumin (BSA) concentration detection has garnered significant interest in drug delivery systems and food industries, assisting in protein stabilization and antibody typing. This paper examines the conventional optical fiber and intracavity laser sensing approaches based on a simple and compact Mach–Zehnder interferometer (MZI) for low-concentration BSA detection. The MZI structure comprises a No core fiber (NCF) -Thin core fiber (TCF)- No core fiber (NCF) spliced between two segments of single mode fiber (SMF). Different BSA concentrations (0&#xa0;mg/mL to 5&#xa0;mg/mL) were dissolved in phosphate-buffered saline (PBS) and tested using the proposed MZI structure. The conventional approach based on a broadband light source (BBS) exhibited a BSA concentration sensitivity of 1.665 nm/(mg/mL), refractive index sensitivity of 6213.33&#xa0;nm/RIU and a low limit of detection (LOD) of 0.012 mg/mL. While the intracavity sensing based on a ring erbium-doped fiber laser (EDFL) cavity showed a BSA concentration sensitivity of − 1.844 nm/(mg/mL), refractive index sensitivity of -6506.67 nm/RIU and a low limit of detection of 0.01 mg/mL. The proposed simple MZI sensors demonstrate excellent repeatability, reusability, and high sensitivity for detecting low-concentration BSA, making them a promising candidate for various biosensing applications.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

No Core-Thin Core-No Core Optical Fiber Sensor Based MZI for in Time Detection of Bovine Serum Albumin

  • 期刊论文

  • 发表日期：

    2025年6月11日

查看全文
  • Wijdan Mhmood Khudhair,
  • Sarah Kadhim Al-Hayali,
  • Abdulhadi Al-Janabi

摘要

Bovine serum albumin (BSA) concentration detection has garnered significant interest in drug delivery systems and food industries, assisting in protein stabilization and antibody typing. This paper examines the conventional optical fiber and intracavity laser sensing approaches based on a simple and compact Mach–Zehnder interferometer (MZI) for low-concentration BSA detection. The MZI structure comprises a No core fiber (NCF) -Thin core fiber (TCF)- No core fiber (NCF) spliced between two segments of single mode fiber (SMF). Different BSA concentrations (0 mg/mL to 5 mg/mL) were dissolved in phosphate-buffered saline (PBS) and tested using the proposed MZI structure. The conventional approach based on a broadband light source (BBS) exhibited a BSA concentration sensitivity of 1.665 nm/(mg/mL), refractive index sensitivity of 6213.33 nm/RIU and a low limit of detection (LOD) of 0.012 mg/mL. While the intracavity sensing based on a ring erbium-doped fiber laser (EDFL) cavity showed a BSA concentration sensitivity of − 1.844 nm/(mg/mL), refractive index sensitivity of -6506.67 nm/RIU and a low limit of detection of 0.01 mg/mL. The proposed simple MZI sensors demonstrate excellent repeatability, reusability, and high sensitivity for detecting low-concentration BSA, making them a promising candidate for various biosensing applications.