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<p>This paper proposes a highly sensitive dual-side polished dual-core PCF (Photonics crystal fiber) based long-range surface plasmon resonance (LRSPR) sensor to measure cortisol concentration in human saliva and track stress levels in real-time.&#xa0;To investigate LRSPR's effects, a thin layer of silver sandwiched between two layers of MgF<sub>2</sub> (Magnesium Fluoride) is used in dual-sided polished PCF. The MgF<sub>2</sub> coating must be functionalized with cysteamine and an anti-cortisol antibody to enable cortisol binding for experimental validation. The finite element method (FEM) built by COMSOL Multiphysics software is used to design the suggested sensor. The results indicate that the best results are obtained by optimizing the pitch value to 0.3&#xa0;μm, the silver layer thickness to 40&#xa0;nm, and the MgF<sub>2</sub> thickness to 350&#xa0;nm. Results demonstrate significantly improved resolution up to 1.806 × 10<sup>–6</sup> RIU, peak Amplitude sensitivity (A.S.) of 5410 (RIU<sup>−1</sup>) with analyte RI 1.38, resonance wavelength 1.14, and wavelength sensitivity 5500&#xa0;nm/RIU, FWHM (140&#xa0;nm) and FOM (39.285 RIU<sup>−1</sup>). The suggested sensor can detect cortisol levels between 0.1 and 30&#xa0;ng/ml.</p>

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Dual Polished-Based Dual Core LRSPR Sensor for Stress Monitoring Using Cortisol Biomarker in Human Saliva

  • 期刊论文

  • 发表日期：

    2025年5月14日

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  • Nitesh Kumar,
  • Sarika Pal,
  • Yogendra Kumar Prajapati

摘要

This paper proposes a highly sensitive dual-side polished dual-core PCF (Photonics crystal fiber) based long-range surface plasmon resonance (LRSPR) sensor to measure cortisol concentration in human saliva and track stress levels in real-time. To investigate LRSPR's effects, a thin layer of silver sandwiched between two layers of MgF2 (Magnesium Fluoride) is used in dual-sided polished PCF. The MgF2 coating must be functionalized with cysteamine and an anti-cortisol antibody to enable cortisol binding for experimental validation. The finite element method (FEM) built by COMSOL Multiphysics software is used to design the suggested sensor. The results indicate that the best results are obtained by optimizing the pitch value to 0.3 μm, the silver layer thickness to 40 nm, and the MgF2 thickness to 350 nm. Results demonstrate significantly improved resolution up to 1.806 × 10–6 RIU, peak Amplitude sensitivity (A.S.) of 5410 (RIU−1) with analyte RI 1.38, resonance wavelength 1.14, and wavelength sensitivity 5500 nm/RIU, FWHM (140 nm) and FOM (39.285 RIU−1). The suggested sensor can detect cortisol levels between 0.1 and 30 ng/ml.