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<p>The present research work highlights the strength of nanostructured hybrid biosensor for detection and monitoring of plasma, hemoglobin and platelets levels of human blood independently. The proposed nanostructured hybrid biosensor is composed of Silver (Ag), Black Phosphorous 2D material (BP) and Cerium oxide (CeO2) layers. It works on the phenomenon of surface plasmon resonance due to involvement of silver in the design. The MATLAB and COMSOL Multiphysics 6.0 simulations based on transfer matrix and finite element method respectively are used to obtain the results of the proposed work. Both normal and infected blood samples containing plasma, hemoglobin and platelet separately are loaded one by one on the top surface of the structure for conducting desired investigations. The proposed hybrid SPR sensor is useful for the early stage diagnosis of dengue virus. The optimized structure [BK7 Prism/Ag (50&#xa0;nm)/BP (5 × 0.53&#xa0;nm)/CeO<sub>2</sub> (1&#xa0;nm) /Sensing medium] loaded with normal and infected hemoglobin sample achieves the enhanced sensitivity of 309°/RIU which is higher than the contemporary SPR biosensors reported earlier. The results of the proposed work demonstrate that the proposed biosensor based on SPR phenomenon can be used as a potential tool for detection of dengue viruses with highly accurate results.</p>

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Surface Plasmon Resonance-Based Hybrid Nanostructured Biosensor Composed of Ag–BP–CeO2 Material Layers: A Theoretical Analysis

  • 期刊论文

  • 发表日期：

    2025年6月4日

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  • Sujit Kumar Saini,
  • Suneet Kumar Awasthi

摘要

The present research work highlights the strength of nanostructured hybrid biosensor for detection and monitoring of plasma, hemoglobin and platelets levels of human blood independently. The proposed nanostructured hybrid biosensor is composed of Silver (Ag), Black Phosphorous 2D material (BP) and Cerium oxide (CeO2) layers. It works on the phenomenon of surface plasmon resonance due to involvement of silver in the design. The MATLAB and COMSOL Multiphysics 6.0 simulations based on transfer matrix and finite element method respectively are used to obtain the results of the proposed work. Both normal and infected blood samples containing plasma, hemoglobin and platelet separately are loaded one by one on the top surface of the structure for conducting desired investigations. The proposed hybrid SPR sensor is useful for the early stage diagnosis of dengue virus. The optimized structure [BK7 Prism/Ag (50 nm)/BP (5 × 0.53 nm)/CeO2 (1 nm) /Sensing medium] loaded with normal and infected hemoglobin sample achieves the enhanced sensitivity of 309°/RIU which is higher than the contemporary SPR biosensors reported earlier. The results of the proposed work demonstrate that the proposed biosensor based on SPR phenomenon can be used as a potential tool for detection of dengue viruses with highly accurate results.