<p>This paper analyzes Comenius’s theoretical and methodological proposals on how human beings acquire knowledge in relation to educational purposes. Comenius emphasizes the harmony between the microcosm and the macrocosm, as well as the doctrine of the <i>imago Dei</i>, which can also be traced in his didactics. However, this concern is not limited solely to the acquisition of knowledge but also seeks to deepen the understanding of the cosmic and divine order, ideas that are explicitly formulated in his Pansophy. Comenius, in particular, emphasized the importance of this harmonious relationship in his theory of knowledge and education, proposing an approach that integrates both the material and spiritual spheres, highlighting the interconnectedness between human beings, the physical universe, and the divine realm. The paper begins by presenting Comenius’s concept of knowledge within the framework of Modern philosophical discussions. Next, it explores Comenius’s syncritic method, which offers an alternative approach to Descartes’s methodology for achieving knowledge of all things. Finally, the paper connects Comenius’s theory of knowledge with the education (Bildung) of human beings, highlighting the implications for human development.</p>