<p>Observations have shown the presence of the Kelvin–Helmholtz instability (KHi) in solar prominences. Effects due to partial ionization of the prominence plasma may influence the KHi onset. We study the triggering of the KHi in an interface model that consists of a partially ionized prominence region and a fully ionized coronal region, with a uniform magnetic field parallel to the interface. There is a longitudinal flow in the prominence region. The plasma is compressible and the role of ambipolar diffusion, which accounts for collisions between charges and neutrals, is taken into account in the prominence plasma. We derive the dispersion relation of linear perturbations on the interface and analyze some limit cases analytically. Numerical results are obtained for realistic prominence parameters. We find that compressibility and gas pressure are important in determining the unstable flow velocities, specially in the range of sub-Alfvénic flows that are consistent with the observations. The ambipolar diffusion has a generally destabilizing influence and reduces the threshold flow velocity for the KHi onset.</p>