<p>The Quality of Life Research Unit was established in 1991 at the Centre for Health Promotion at the University of Toronto for the purpose of developing an instrument package for assessing the quality of life of people with developmental disabilities. Over the following 30 years it carried out projects that developed and validated a variety of additional quality of life instruments that came to be employed in research and practice activities across the globe. The Unit has ceased to operate but has made available the instruments developed during its operation. These include measures of quality of life of people with developmental disabilities, people with physical and sensory disabilities, and people with schizophrenia. It also developed and has made available instruments for use with general populations of adolescents, adults, and seniors, and a process for assessing community quality of life. In this time of threats to the welfare state and decaying public policy environments, the availability of these instruments can allow researchers and workers to assess the effects of these threats on the quality of life of individuals in general, those with specific disabilities, and the communities in which they reside. This article reviews these instruments and their applications and makes the case for renewed use of them for assessing the effects of the contemporary neoliberalism-inspired polycrisis.</p>