<p>The structural characteristics of inclined layered slopes play a decisive role in their failure modes. Once such slopes fail, they can easily trigger severe geological hazards. Therefore, studying the effect of multiple joint distributions on the failure of inclined slopes is of great significance. This study uses the particle flow code method to simulate centrifuge tests, establishes a model of an inclined slope with multiple joints, and verifies its reliability. The slope failure process is divided into four stages: cracking at the rear edge of the slope; cracking at the front edge of the slope; collapse at the toe of the slope; and overall failure. The slope failure mechanism is analyzed according to various aspects, including the deformation characteristics, crack distribution, force chain distribution, slope block fragmentation, energy, and crack evolution. The deformation of the slope is concentrated at the front edge, while the failure of the slope extends to the interior of the slope mass. The stress changes in the slope primarily occur above the toe of the slope. During the slope failure process, the frictional energy generated is the largest, followed by the kinetic energy, and then the strain energy. The strain energy initially increases and then decreases, while the kinetic energy increases, decreases, and then increases again. The frictional energy rapidly increases and then slowly increases.</p>