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<p>The furan ring opening reaction in substituted ethyl 4-aryl-2-[(5-aryl-2-oxofuran-3(2<i>H</i>)-ylidene)amino]thiophen-3-carboxylates under the action of cyanoacetic acid derivatives and sodium carbonate was studied and found to proceed with the formation of new substituted sodium 5-aryl-3-{[4-aryl-3-(ethoxycarbonyl)thiophen-2-yl]amino}-1-cyano-5-oxopenta-1,3-dien-2-olates. The anthelmintic activity of the obtained compounds was investigated by <i>in vitro</i> methods. The test compounds demonstrated pronounced antiparasitic efficacy, which makes them a promising basis for the development of anthelmintic drugs.</p>

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Synthesis and investigation of the anthelmintic activity of substituted sodium 5-aryl-1-cyano-3-{[3-(ethoxycarbonyl)thiophen-2-yl]amino}-5-oxopenta-1,3-dien-2-olates

  • 期刊论文

  • 发表日期：

    2026年2月1日

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  • D. A. Kozlov,
  • D. V. Lipin,
  • I. A. Gorbunova,
  • A. V. Starkova,
  • O. Yu. Ustinova,
  • P. S. Silaychev,
  • D. A. Shipilovskikh,
  • S. A. Shipilovskikh

摘要

The furan ring opening reaction in substituted ethyl 4-aryl-2-[(5-aryl-2-oxofuran-3(2H)-ylidene)amino]thiophen-3-carboxylates under the action of cyanoacetic acid derivatives and sodium carbonate was studied and found to proceed with the formation of new substituted sodium 5-aryl-3-{[4-aryl-3-(ethoxycarbonyl)thiophen-2-yl]amino}-1-cyano-5-oxopenta-1,3-dien-2-olates. The anthelmintic activity of the obtained compounds was investigated by in vitro methods. The test compounds demonstrated pronounced antiparasitic efficacy, which makes them a promising basis for the development of anthelmintic drugs.