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<p>The synthesis of quaternary ammonium salts containing 1,3-dioxolane and <i>gem</i>-dichlorocyclopropane fragments based on <i>N</i>,<i>N</i>-dimethylpropylenediamine under heating conditions is described. Quaternary ammonium salts obtained exchibit antiaggregatory activity at the level of acetylsalicylic acid according to the value of the maximum amplitude of aggregation, while they are more effective than the comparison drug in prolonging the platelet release reaction. This may indicate their broader antithrombotic potential.</p>

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Synthesis and biological activity of N,N-dimethylpropylenediamine derivatives containing a cyclic acetal or gem-dichlorocyclopropane fragment

  • 期刊论文

  • 发表日期：

    2026年2月1日

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  • G. Z. Raskildina,
  • Yu. G. Borisova,
  • N. I. Medvedeva,
  • S. S. Zlotsky,
  • A. N. Kuzovlev,
  • A. V. Samorodov

摘要

The synthesis of quaternary ammonium salts containing 1,3-dioxolane and gem-dichlorocyclopropane fragments based on N,N-dimethylpropylenediamine under heating conditions is described. Quaternary ammonium salts obtained exchibit antiaggregatory activity at the level of acetylsalicylic acid according to the value of the maximum amplitude of aggregation, while they are more effective than the comparison drug in prolonging the platelet release reaction. This may indicate their broader antithrombotic potential.