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<p>The reactions of 5-substituted 3,4-dichloro-2(5<i>H</i>)-furanone derivatives with 5-mercapto-1-phenyltetrazole in the presence of triethylamine afforded a series of heterocycles containing the tetrazolylsulfanyl moiety at the carbon atom C(4) of the lactone ring. The structures of four new 1,5-disubstituted tetrazoles were established by X-ray diffraction. A number of heterocycles were found to exhibit moderate antifungal activity against <i>Aspergillus niger, Fusarium solani, Candida albicans</i>, and <i>Alternaria alternata</i>; however, none of the compounds possessed antibacterial activity.</p>

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Synthesis and fungicidal activity of tetrazole-containing thioethers of the 2(5H)-furanone series

  • 期刊论文

  • 发表日期：

    2026年1月1日

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  • E. Sh. Saigitbatalova,
  • N. S. Charushin,
  • L. Z. Latypova,
  • S. V. Kolyshkina,
  • D. P. Gerasimova,
  • D. A. Novichikhina,
  • O. A. Lodochnikova,
  • A. R. Kayumov,
  • A. R. Kurbangalieva

摘要

The reactions of 5-substituted 3,4-dichloro-2(5H)-furanone derivatives with 5-mercapto-1-phenyltetrazole in the presence of triethylamine afforded a series of heterocycles containing the tetrazolylsulfanyl moiety at the carbon atom C(4) of the lactone ring. The structures of four new 1,5-disubstituted tetrazoles were established by X-ray diffraction. A number of heterocycles were found to exhibit moderate antifungal activity against Aspergillus niger, Fusarium solani, Candida albicans, and Alternaria alternata; however, none of the compounds possessed antibacterial activity.