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<p>2-Arylmethylidene-4,5-dichlorocyclopent-4-ene-1,3-diones were synthesized by aldol condensation of 4,5-dichlorocyclopent-4-ene-1,3-dione with 3,5-di-<i>tert</i>-butyl- and 3,5-diisopropyl-4-hydroxybenzaldehydes. The substitution of chlorine atoms at the C5 atoms of the obtained compounds with some N-, O-, and C-nucleophiles was studied. The synthesized compounds showed high and moderate cytotoxicity against studied tumor cell lines (Hek293, HCT-116, MSF7, HepG2, Jurkat) in <i>in vitro</i> experiments.</p>

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New cytotoxic cross-conjugated cyclopentenediones from 4,5-dichlorocyclopent-4-ene-1,3-dione

  • 期刊论文

  • 发表日期：

    2026年1月1日

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  • V. A. Egorov,
  • L. S. Khasanova,
  • F. A. Gimalova,
  • A. N. Lobov,
  • D. V. Ishmetova,
  • V. A. Vakhitov,
  • M. S. Miftakhov

摘要

2-Arylmethylidene-4,5-dichlorocyclopent-4-ene-1,3-diones were synthesized by aldol condensation of 4,5-dichlorocyclopent-4-ene-1,3-dione with 3,5-di-tert-butyl- and 3,5-diisopropyl-4-hydroxybenzaldehydes. The substitution of chlorine atoms at the C5 atoms of the obtained compounds with some N-, O-, and C-nucleophiles was studied. The synthesized compounds showed high and moderate cytotoxicity against studied tumor cell lines (Hek293, HCT-116, MSF7, HepG2, Jurkat) in in vitro experiments.