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<p>A metal-free oxidation of 1-benzyl-3,4-dihydroisoquinolines to 1-benzoyl-3,4-di-hydroisoquinolines was accomplished using dioxygen as an oxidant. This protocol provides a facile route for the efficient synthesis of isoquinoline alkaloids. Mechanistic investigation suggested that ionic pathway is the major route in the reaction and 1-[hydroxyperoxy(phenyl)-methyl]-6,7-dimethoxy-3,4-dihydroisoquinoline may be the key intermediate for the formation of the products.</p>

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Metal-free oxidation of 1-benzyl-3,4-dihydroisoquinolines to 1-benzoyl-3,4-dihydroisoquinolines with dioxygen as an oxidant

  • 期刊论文

  • 发表日期：

    2025年11月1日

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  • Peipei Ma,
  • Hongli Wu,
  • Haifeng Gan

摘要

A metal-free oxidation of 1-benzyl-3,4-dihydroisoquinolines to 1-benzoyl-3,4-di-hydroisoquinolines was accomplished using dioxygen as an oxidant. This protocol provides a facile route for the efficient synthesis of isoquinoline alkaloids. Mechanistic investigation suggested that ionic pathway is the major route in the reaction and 1-[hydroxyperoxy(phenyl)-methyl]-6,7-dimethoxy-3,4-dihydroisoquinoline may be the key intermediate for the formation of the products.