New tetrahydrobenzo[b][1,6]naphthyridine derivatives: synthesis and biological activity

期刊论文
发表日期：

2025年10月1日

查看全文

L. N. Kulikova,
G. F. Makhaeva,
G. R. Raesi,
A. P. Novikov,
V. N. Tumasov,
M. B Rakhimdzhanova,
N. V. Kovaleva,
E. V. Rudakova,
N. P. Boltneva,
O. G. Serebryakova,
N. Q. Shikhaliyev,
L. G. Voskressensky

摘要

Microwave-assisted reactions of 10-chlorotetrahydrobenzo[b][1,6]naphthyridines with N-, S-, and C-nucleophiles resulted in the introduction of various structural moieties in position 10 to give new tetrahydrobenzo[b][1,6]naphthyridine derivatives. Substituted 10-phenyl tetrahydrobenzo[b][1,6]naphthyridines were modified at the nitrogen atom of the tetrahydropyridine moiety using activated alkynes. The esterase profile and the antioxidant activity of the obtained compounds were studied. A compound active towards acetylcholinesterase (IC₅₀ = 15.0±0.9 µmol L⁻¹) and a number of compounds selectively inhibiting butyrylcholinesterase (IC₅₀ of up to 17.5±1.4 µmol L⁻¹) were identified. Compounds with a moderate antioxidant activity in ABTS and FRAP assays were found.