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<p>10-(Chloroacetyl)phenothiazine reacted with 2-thioxo-1,2-dihydronicotinonitriles in the presence of KOH to form 2-{[2-oxo-2-(10<i>H</i>-phenothiazin-10-yl)ethyl]thio}nicotinonitriles or (3-aminothieno[2,3-<i>b</i>]pyridin-2-yl)(10<i>H</i>-phenothiazin-10-yl)methanones. Some of the synthesized compounds manifested herbicide safening effects against 2,4-D herbicide under conditions of laboratory experiments on sunflower seedlings. According to the results of molecular docking, the nicotinonitrile—phenothiazine heterodimers were found to be promising modulators of the PI3K/AKT/mTOR signaling pathway and of interest as potential antitumor agents.</p>

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Synthesis and biological activity of new phenothiazine-based heterodimers

  • 期刊论文

  • 发表日期：

    2025年10月1日

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  • O. A. Andrianova,
  • D. S. Buryi,
  • N. O. Gluzmin,
  • E. S. Daus,
  • V. V. Dotsenko,
  • Vl. K. Kindop,
  • V. K. Kindop,
  • D. D. Kosenko,
  • V. D. Strelkov,
  • T. L. Tsymbal,
  • K. V. Gordeev,
  • N. A. Aksenov,
  • I. V. Aksenova

摘要

10-(Chloroacetyl)phenothiazine reacted with 2-thioxo-1,2-dihydronicotinonitriles in the presence of KOH to form 2-{[2-oxo-2-(10H-phenothiazin-10-yl)ethyl]thio}nicotinonitriles or (3-aminothieno[2,3-b]pyridin-2-yl)(10H-phenothiazin-10-yl)methanones. Some of the synthesized compounds manifested herbicide safening effects against 2,4-D herbicide under conditions of laboratory experiments on sunflower seedlings. According to the results of molecular docking, the nicotinonitrile—phenothiazine heterodimers were found to be promising modulators of the PI3K/AKT/mTOR signaling pathway and of interest as potential antitumor agents.